CompMoby incorporates evolutionary conservation information with the existing MobyDick algorithm to detect over-represented motifs in the upstream or 3' UTR sequences of co-expressed genes.
For examples, download zip file containing all sample input files for upstream promoter or 3' UTR sequences for test run.|
Explanation of the results of the upstream promoter example can be found here.
|It is recommended that you RepeatMask all your input sequences before running CompMoby.|
2. Grskovic, M.*, Chaivorapol, C.*, Gaspar-Maia, A.*, Li, H., and Ramalho-Santos, M. Systematic identification of cis-regulatory sequences active in mouse and human embryonic stem cells. PLoS Genetics (2007).
3. Bussemaker, H.J., Li H., and Siggia, E.D. Regulatory element detection using a probabilistic segmentation model. ISMB. (2000).
4. Bussemaker, H.J., Li, H., and Siggia, E.D. Building a dictionary for genomes: identification of presumptive regulatory sites by statistical analysis. PNAS (2000).
(Last updated: November 11, 2008)