#Accession No.Genes Z_l AvgLength TermDescription GO:0008202 25 7.142 249 steroid metabolism GO:0006066 84 7.07 192.3 alcohol metabolism GO:0016126 20 6.7 253.6 sterol biosynthesis GO:0016125 20 6.7 253.6 sterol metabolism GO:0006694 24 6.635 251.1 steroid biosynthesis GO:0008204 18 6.041 246.4 ergosterol metabolism GO:0006696 18 6.041 246.4 ergosterol biosynthesis GO:0006096 12 5.919 275.8 glycolysis GO:0046365 15 5.823 252.7 monosaccharide catabolism GO:0019320 15 5.823 252.7 hexose catabolism GO:0006007 15 5.823 252.7 glucose catabolism GO:0016052 23 5.608 225.7 carbohydrate catabolism GO:0046164 17 5.357 233.6 alcohol catabolism GO:0005975 107 5.207 165.6 carbohydrate metabolism GO:0006006 33 5.194 200.5 glucose metabolism GO:0019318 45 4.988 187.6 hexose metabolism GO:0015980 103 4.713 163.3 energy derivation by oxidation of organic compounds GO:0006091 103 4.713 163.3 energy pathways GO:0016772 191 4.697 151.3 transferase activity, transferring phosphorus-containing groups GO:0016773 121 4.668 160.6 phosphotransferase activity, alcohol group as acceptor GO:0016301 142 4.654 157.6 kinase activity GO:0030312 40 4.639 188.3 external encapsulating structure GO:0009277 40 4.639 188.3 cell wall (sensu Fungi) GO:0005618 40 4.639 188.3 cell wall GO:0006092 39 4.339 182.6 main pathways of carbohydrate metabolism GO:0006629 121 4.187 156.4 lipid metabolism GO:0005996 50 4.18 177.5 monosaccharide metabolism GO:0016564 11 4.18 237.6 transcriptional repressor activity GO:0009653 70 4.131 166.9 morphogenesis GO:0000902 70 4.131 166.9 cellular morphogenesis GO:0019200 11 4.108 235.9 carbohydrate kinase activity GO:0040007 47 4.012 176.6 growth GO:0016538 15 4.01 211.9 cyclin-dependent protein kinase, intrinsic regulator activity GO:0030447 46 3.98 174 filamentous growth GO:0007150 46 3.98 174 growth pattern GO:0016491 122 3.977 152.9 oxidoreductase activity GO:0004674 60 3.943 167.4 protein serine/threonine kinase activity GO:0016740 395 3.943 139.2 transferase activity GO:0008610 80 3.93 163.4 lipid biosynthesis GO:0000082 30 3.866 185.7 G1/S transition of mitotic cell cycle GO:0019740 10 3.827 230.3 nitrogen utilization GO:0005933 84 3.805 160 bud GO:0006807 23 3.687 189.1 nitrogen metabolism GO:0004693 20 3.615 192.2 cyclin-dependent protein kinase activity GO:0004672 95 3.605 156.2 protein kinase activity GO:0030528 188 3.533 144.8 transcription regulator activity GO:0006796 97 3.53 152.4 phosphate metabolism GO:0006793 97 3.53 152.4 phosphorus metabolism GO:0005934 34 3.372 174.1 bud tip GO:0005215 206 3.362 142.4 transporter activity GO:0006869 10 3.331 216.5 lipid transport GO:0005386 58 3.323 161 carrier activity GO:0019887 17 3.248 189.5 protein kinase regulator activity GO:0008361 7 3.223 229 regulation of cell size GO:0005489 14 3.202 200.1 electron transporter activity GO:0004553 15 3.125 191.1 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0045229 78 3.098 154.4 external encapsulating structure organization and biogenesis GO:0007047 78 3.098 154.4 cell wall organization and biogenesis GO:0000086 19 3.084 183.4 G2/M transition of mitotic cell cycle GO:0030483 86 2.985 151.2 site of polarized growth (sensu Fungi) GO:0030427 86 2.985 151.2 site of polarized growth GO:0000134 86 2.985 151.2 site of polarized growth (sensu Saccharomyces) GO:0016051 39 2.982 163.7 carbohydrate biosynthesis GO:0006355 169 2.967 141.6 regulation of transcription, DNA-dependent GO:0019752 126 2.96 145.1 carboxylic acid metabolism GO:0006082 126 2.96 145.1 organic acid metabolism GO:0007275 205 2.934 140.8 development GO:0007124 29 2.926 168.9 pseudohyphal growth GO:0005976 25 2.916 173.5 polysaccharide metabolism GO:0006357 100 2.905 147.7 regulation of transcription from Pol II promoter GO:0005886 100 2.905 147.4 plasma membrane GO:0045449 175 2.892 142 regulation of transcription GO:0009058 477 2.846 133.9 biosynthesis GO:0000079 9 2.838 208.6 regulation of CDK activity GO:0006118 11 2.818 199.1 electron transport GO:0006633 7 2.807 215.3 fatty acid biosynthesis GO:0006094 20 2.806 176.9 gluconeogenesis GO:0003824 1075 2.798 129.1 catalytic activity GO:0046483 42 2.788 159.1 heterocycle metabolism GO:0042626 23 2.78 173 ATPase activity, coupled to transmembrane movement of substances GO:0016820 23 2.78 173 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0015405 23 2.78 173 P-P-bond-hydrolysis-driven transporter activity GO:0040020 11 2.747 197 regulation of meiosis GO:0003704 28 2.746 169.4 specific RNA polymerase II transcription factor activity GO:0005199 6 2.732 224.7 structural constituent of cell wall GO:0015846 6 2.705 223.3 polyamine transport GO:0016798 20 2.704 174.3 hydrolase activity, acting on glycosyl bonds GO:0006164 28 2.688 168.4 purine nucleotide biosynthesis GO:0015399 31 2.679 164.2 primary active transporter activity GO:0016903 8 2.673 206.6 oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0016310 76 2.657 149.1 phosphorylation GO:0006113 6 2.651 221.8 fermentation GO:0015926 9 2.642 202.6 glucosidase activity GO:0007154 110 2.63 144.8 cell communication GO:0016879 31 2.617 163.7 ligase activity, forming carbon-nitrogen bonds GO:0009165 31 2.617 163.5 nucleotide biosynthesis GO:0006163 30 2.609 164.2 purine nucleotide metabolism GO:0048066 9 2.609 201.2 pigmentation GO:0046148 9 2.609 201.2 pigment biosynthesis GO:0042440 9 2.609 201.2 pigment metabolism GO:0042168 9 2.609 201.2 heme metabolism GO:0006783 9 2.609 201.2 heme biosynthesis GO:0006779 9 2.609 201.2 porphyrin biosynthesis GO:0006778 9 2.609 201.2 porphyrin metabolism GO:0003700 27 2.596 167.6 transcription factor activity GO:0001403 17 2.577 175.1 invasive growth (sensu Saccharomyces) GO:0007096 6 2.57 218.2 regulation of exit from mitosis GO:0006631 23 2.567 168.2 fatty acid metabolism GO:0016769 8 2.547 202.2 transferase activity, transferring nitrogenous groups GO:0008483 8 2.547 202.2 transaminase activity GO:0046165 22 2.516 170.2 alcohol biosynthesis GO:0015075 61 2.503 151.1 ion transporter activity GO:0006073 18 2.494 172.5 glucan metabolism GO:0030120 20 2.401 168.6 vesicle coat GO:0046364 21 2.368 168.6 monosaccharide biosynthesis GO:0019319 21 2.368 168.6 hexose biosynthesis GO:0030004 14 2.35 179.6 monovalent inorganic cation homeostasis GO:0006112 16 2.339 175.2 energy reserve metabolism GO:0006468 58 2.302 148.3 protein amino acid phosphorylation GO:0000271 13 2.3 179.8 polysaccharide biosynthesis GO:0000122 23 2.3 163.7 negative regulation of transcription from Pol II promoter GO:0006665 18 2.255 167.6 sphingolipid metabolism GO:0007165 100 2.233 141.6 signal transduction GO:0042775 7 2.211 195.4 ATP synthesis coupled electron transport (sensu Eukarya) GO:0042773 7 2.211 195.4 ATP synthesis coupled electron transport GO:0006129 7 2.211 195.4 protein-disulfide reduction GO:0003714 8 2.202 191.8 transcription co-repressor activity GO:0009117 37 2.189 152.9 nucleotide metabolism GO:0008135 32 2.175 154.1 translation factor activity, nucleic acid binding GO:0046394 11 2.173 181.6 carboxylic acid biosynthesis GO:0016053 11 2.173 181.6 organic acid biosynthesis GO:0008324 49 2.159 149.5 cation transporter activity GO:0007242 60 2.143 147 intracellular signaling cascade GO:0006414 11 2.137 180.6 translational elongation GO:0008652 57 2.133 146.7 amino acid biosynthesis GO:0019207 24 2.121 163.1 kinase regulator activity GO:0030641 10 2.094 181.6 hydrogen ion homeostasis GO:0006885 10 2.094 181.6 regulation of pH GO:0019222 21 2.068 162.3 regulation of metabolism GO:0009435 6 2.059 199.2 nicotinamide adenine dinucleotide biosynthesis GO:0009309 60 2.057 145.4 amine biosynthesis GO:0009894 7 2.033 189.6 regulation of catabolism GO:0007264 36 2.029 150.6 small GTPase mediated signal transduction GO:0030148 13 2.026 172.9 sphingolipid biosynthesis GO:0045182 38 2.024 151.6 translation regulator activity GO:0015203 9 2.019 183.7 polyamine transporter activity GO:0007088 18 2.015 162.6 regulation of mitosis GO:0000131 18 2.015 162.5 incipient bud site GO:0016638 6 2.005 197.3 oxidoreductase activity, acting on the CH-NH2 group of donors GO:0003746 10 1.987 178.9 translation elongation factor activity GO:0006090 6 1.978 196.5 pyruvate metabolism GO:0006087 6 1.978 196.5 pyruvate dehydrogenase bypass GO:0004871 40 1.954 149.5 signal transducer activity GO:0006099 9 1.953 181.4 tricarboxylic acid cycle GO:0000307 6 1.951 195 cyclin-dependent protein kinase holoenzyme complex GO:0016616 30 1.951 153.2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005941 20 1.946 159.9 unlocalized GO:0005935 62 1.94 143.7 bud neck GO:0006513 12 1.936 171.5 protein monoubiquitination GO:0004009 12 1.936 171.3 ATP-binding cassette (ABC) transporter activity GO:0030117 23 1.927 156.9 membrane coat GO:0042625 11 1.923 174.7 ATPase activity, coupled to transmembrane movement of ions GO:0000209 11 1.923 174.4 protein polyubiquitination GO:0006100 9 1.92 180.9 TCA intermediate metabolism GO:0007015 37 1.913 148.6 actin filament organization GO:0003702 78 1.866 141.6 RNA polymerase II transcription factor activity GO:0009112 20 1.845 157 nucleobase metabolism GO:0004872 12 1.821 168.7 receptor activity GO:0016481 64 1.815 142.3 negative regulation of transcription GO:0005937 24 1.814 157.7 shmoo tip GO:0006413 25 1.804 153.4 translational initiation GO:0016651 8 1.795 178.2 oxidoreductase activity, acting on NADH or NADPH GO:0016614 37 1.775 147 oxidoreductase activity, acting on CH-OH group of donors GO:0019674 8 1.763 177.5 nicotinamide adenine dinucleotide metabolism GO:0006520 81 1.763 139 amino acid metabolism GO:0006519 88 1.745 137.4 amino acid and derivative metabolism GO:0006873 48 1.738 143.9 cell ion homeostasis GO:0016020 468 1.719 128.3 membrane GO:0005746 12 1.706 165.6 mitochondrial electron transport chain GO:0008134 20 1.693 154.9 transcription factor binding GO:0006811 50 1.691 145 ion transport GO:0006144 10 1.669 169.5 purine base metabolism GO:0045941 33 1.656 146.4 positive regulation of transcription GO:0042598 7 1.646 176.1 vesicular fraction GO:0005792 7 1.646 176.1 microsome GO:0003743 19 1.645 154.5 translation initiation factor activity GO:0009991 6 1.627 183.5 response to extracellular stimulus GO:0005319 9 1.593 170.2 lipid transporter activity GO:0007568 20 1.592 152.7 aging GO:0008509 12 1.592 162.7 anion transporter activity GO:0005977 12 1.592 162.2 glycogen metabolism GO:0015291 15 1.577 156.4 porter activity GO:0015290 15 1.577 156.4 electrochemical potential-driven transporter activity GO:0030003 41 1.57 143.8 cation homeostasis GO:0019363 7 1.556 173 pyridine nucleotide biosynthesis GO:0006820 13 1.556 160.2 anion transport GO:0015078 23 1.553 149.1 hydrogen ion transporter activity GO:0046112 12 1.553 161.3 nucleobase biosynthesis GO:0030036 50 1.541 142.3 actin cytoskeleton organization and biogenesis GO:0015077 25 1.526 148.2 monovalent inorganic cation transporter activity GO:0030234 101 1.513 134.4 enzyme regulator activity GO:0016620 6 1.493 178.3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0045892 63 1.49 139.9 negative regulation of transcription, DNA-dependent GO:0006119 18 1.488 151.5 oxidative phosphorylation GO:0006366 157 1.461 132.4 transcription from Pol II promoter GO:0016567 14 1.456 157.6 protein ubiquitination GO:0004722 21 1.418 149.2 protein serine/threonine phosphatase activity GO:0016765 24 1.403 149 transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0042592 54 1.394 138.7 homeostasis GO:0019725 54 1.394 138.7 cell homeostasis GO:0030029 52 1.385 138.8 actin filament-based process GO:0009308 98 1.373 134.6 amine metabolism GO:0016874 58 1.367 137 ligase activity GO:0016763 12 1.362 156.2 transferase activity, transferring pentosyl groups GO:0015711 6 1.358 173.7 organic anion transport GO:0007035 6 1.358 173.8 vacuolar acidification GO:0003697 6 1.358 173 single-stranded DNA binding GO:0045893 30 1.352 144 positive regulation of transcription, DNA-dependent GO:0005829 173 1.344 130.7 cytosol GO:0019856 8 1.324 163.8 pyrimidine base biosynthesis GO:0016265 21 1.318 147.8 death GO:0000074 64 1.298 136.1 regulation of cell cycle GO:0003712 18 1.296 147.2 transcription cofactor activity GO:0019362 22 1.29 146.6 pyridine nucleotide metabolism GO:0006769 22 1.29 146.6 nicotinamide metabolism GO:0005548 7 1.289 164 phospholipid transporter activity GO:0030137 13 1.281 153.5 COPI-coated vesicle GO:0016582 57 1.278 136.7 non-covalent chromatin modification GO:0006338 57 1.278 136.7 chromatin modeling GO:0007569 19 1.248 146.5 cell aging GO:0009084 13 1.242 152.6 glutamine family amino acid biosynthesis GO:0000790 22 1.239 145.9 nuclear chromatin GO:0046219 8 1.23 160.5 indolalkylamine biosynthesis GO:0042435 8 1.23 160.5 indole derivative biosynthesis GO:0042434 8 1.23 160.5 indole derivative metabolism GO:0042430 8 1.23 160.5 indole and derivative metabolism GO:0009096 8 1.23 160.5 aromatic amino acid family biosynthesis, anthranilate pathway GO:0006586 8 1.23 160.5 indolalkylamine metabolism GO:0006568 8 1.23 160.5 tryptophan metabolism GO:0000162 8 1.23 160.5 tryptophan biosynthesis GO:0005811 21 1.218 145.6 lipid particle GO:0006725 35 1.213 139.5 aromatic compound metabolism GO:0009082 10 1.209 156.1 branched chain family amino acid biosynthesis GO:0009250 9 1.167 157.2 glucan biosynthesis GO:0019932 13 1.164 150.6 second-messenger-mediated signaling GO:0016563 24 1.147 144.8 transcriptional activator activity GO:0005789 63 1.146 135.6 endoplasmic reticulum membrane GO:0005100 6 1.143 165.5 Rho GTPase activator activity GO:0030468 52 1.142 135.6 establishment of cell polarity (sensu Fungi) GO:0030010 52 1.142 135.6 establishment of cell polarity GO:0000283 52 1.142 135.6 establishment of cell polarity (sensu Saccharomyces) GO:0009081 11 1.134 152.6 branched chain family amino acid metabolism GO:0006512 26 1.127 141.4 ubiquitin cycle GO:0016311 16 1.121 147.9 dephosphorylation GO:0007117 16 1.077 146 bud growth GO:0000785 23 1.073 140.8 chromatin GO:0004659 10 1.068 152.6 prenyltransferase activity GO:0005083 33 1.066 137.2 small GTPase regulatory/interacting protein activity GO:0042401 11 1.063 150.1 biogenic amine biosynthesis GO:0004428 6 1.062 162.7 inositol/phosphatidylinositol kinase activity GO:0042398 12 1.055 148 amino acid derivative biosynthesis GO:0009266 8 1.042 154.6 response to temperature GO:0005576 9 1.035 153.4 extracellular GO:0008219 20 1.035 141.7 cell death GO:0006914 22 1.035 141.6 autophagy GO:0004842 16 1.034 145.6 ubiquitin-protein ligase activity GO:0004721 32 1.026 136.7 protein phosphatase activity GO:0045944 25 1.025 139.8 positive regulation of transcription from Pol II promoter GO:0019438 13 1.007 146.4 aromatic compound biosynthesis GO:0009073 13 1.007 146.4 aromatic amino acid family biosynthesis GO:0042175 72 1.007 132.4 nuclear envelope-endoplasmic reticulum network GO:0046138 43 1.006 134.8 coenzymes and prosthetic group biosynthesis GO:0042623 55 1.005 133.8 ATPase activity, coupled GO:0006790 30 0.993 137.9 sulfur metabolism GO:0006731 75 0.993 132.4 coenzymes and prosthetic group metabolism GO:0016585 11 0.991 148.4 chromatin remodeling complex GO:0030880 20 0.985 140.5 RNA polymerase complex GO:0019935 8 0.979 152.1 cyclic-nucleotide-mediated signaling GO:0019933 8 0.979 152.1 cAMP-mediated signaling GO:0007093 9 0.97 151.7 mitotic checkpoint GO:0019751 6 0.954 158.8 polyol metabolism GO:0006071 6 0.954 158.8 glycerol metabolism GO:0008320 8 0.948 151.8 protein carrier activity GO:0009260 17 0.946 141 ribonucleotide biosynthesis GO:0009152 17 0.946 141 purine ribonucleotide biosynthesis GO:0009064 17 0.946 141.8 glutamine family amino acid metabolism GO:0030467 53 0.946 134.5 establishment and/or maintenance of cell polarity (sensu Fungi) GO:0030012 53 0.946 134.5 establishment and/or maintenance of cell polarity (sensu Saccharomyces) GO:0007163 53 0.946 134.5 establishment and/or maintenance of cell polarity GO:0006890 11 0.919 146.2 retrograde (Golgi to ER) transport GO:0003899 21 0.918 139.1 DNA-directed RNA polymerase activity GO:0006575 15 0.913 141 amino acid derivative metabolism GO:0006734 6 0.9 156.7 NADH metabolism GO:0006555 14 0.888 143.9 methionine metabolism GO:0006470 14 0.888 143.9 protein amino acid dephosphorylation GO:0006445 14 0.888 143.7 regulation of translation GO:0046486 8 0.885 149 glycerolipid metabolism GO:0006662 8 0.885 149 glycerol ether metabolism GO:0006641 8 0.885 149 triacylglycerol metabolism GO:0006639 8 0.885 149 acylglycerol metabolism GO:0006638 8 0.885 149 neutral lipid metabolism GO:0005679 8 0.885 149.2 nucleosome remodeling complex GO:0009060 35 0.879 134.7 aerobic respiration GO:0007265 12 0.864 143.8 RAS protein signal transduction GO:0045047 16 0.859 141.9 protein-ER targeting GO:0007266 10 0.856 146.8 Rho protein signal transduction GO:0000137 8 0.854 148.9 Golgi cis cisterna GO:0006576 14 0.847 142.1 biogenic amine metabolism GO:0015662 6 0.846 154.5 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0008535 6 0.846 154.5 cytochrome c oxidase biogenesis GO:0006462 6 0.846 154.5 protein complex assembly, multichaperone pathway GO:0016568 92 0.841 129.3 chromatin modification GO:0040029 39 0.839 133.9 regulation of gene expression, epigenetic GO:0006812 36 0.835 133.6 cation transport GO:0016881 22 0.831 137.4 acid-D-amino acid ligase activity GO:0009072 15 0.825 139.3 aromatic amino acid family metabolism GO:0008514 8 0.823 147.2 organic anion transporter activity GO:0008028 8 0.823 147.2 monocarboxylic acid transporter activity GO:0006206 10 0.785 144.5 pyrimidine base metabolism GO:0005774 49 0.782 131.3 vacuolar membrane GO:0005758 15 0.781 138.7 mitochondrial intermembrane space GO:0007231 9 0.773 145.1 osmosensory signaling pathway GO:0005940 9 0.773 145.7 septin ring GO:0003677 107 0.766 127.7 DNA binding GO:0030127 6 0.765 151 COPII vesicle coat GO:0016627 8 0.76 145.9 oxidoreductase activity, acting on the CH-CH group of donors GO:0007029 17 0.755 137.4 ER organization and biogenesis GO:0006733 30 0.754 133.2 oxidoreduction coenzyme metabolism GO:0005275 23 0.753 134.2 amine/polyamine transporter activity GO:0006791 7 0.753 146.7 sulfur utilization GO:0000103 7 0.753 146.7 sulfate assimilation GO:0000075 19 0.751 136.7 cell cycle checkpoint GO:0000183 10 0.749 143.7 chromatin silencing at ribosomal DNA (rDNA) GO:0019866 84 0.737 128.2 inner membrane GO:0005743 84 0.737 128.2 mitochondrial inner membrane GO:0015992 13 0.733 139.3 proton transport GO:0015672 13 0.733 139.3 monovalent inorganic cation transport GO:0006818 13 0.733 139.3 hydrogen transport GO:0006348 20 0.732 135.4 chromatin silencing at telomere GO:0019205 6 0.711 149.3 nucleobase, nucleoside, nucleotide kinase activity GO:0005887 12 0.711 139 integral to plasma membrane GO:0004407 12 0.711 139.9 histone deacetylase activity GO:0009076 9 0.708 143.7 histidine family amino acid biosynthesis GO:0009075 9 0.708 143.7 histidine family amino acid metabolism GO:0006547 9 0.708 143.7 histidine metabolism GO:0000105 9 0.708 143.7 histidine biosynthesis GO:0005783 217 0.702 125.4 endoplasmic reticulum GO:0007582 2387 0.701 123.4 physiological processes GO:0009066 23 0.7 133.7 aspartate family amino acid metabolism GO:0030125 8 0.697 143.2 clathrin vesicle coat GO:0030118 8 0.697 143.2 clathrin coat GO:0045333 36 0.695 131 cellular respiration GO:0042546 6 0.685 148.8 cell wall biosynthesis GO:0009272 6 0.685 148.8 cell wall biosynthesis (sensu Fungi) GO:0007120 10 0.679 141.5 axial budding GO:0006970 34 0.676 131.4 response to osmotic stress GO:0009259 18 0.673 134.7 ribonucleotide metabolism GO:0009150 18 0.673 134.7 purine ribonucleotide metabolism GO:0000151 17 0.659 135.2 ubiquitin ligase complex GO:0009127 6 0.658 147 purine nucleoside monophosphate biosynthesis GO:0009124 6 0.658 147 nucleoside monophosphate biosynthesis GO:0006875 28 0.654 133.1 metal ion homeostasis GO:0019867 15 0.648 135.2 outer membrane GO:0005741 15 0.648 135.2 mitochondrial outer membrane GO:0006950 209 0.647 125.2 response to stress GO:0006350 372 0.646 124.4 transcription GO:0009067 10 0.643 140.9 aspartate family amino acid biosynthesis GO:0006613 10 0.643 140.8 cotranslational membrane targeting GO:0016747 43 0.64 129.2 transferase activity, transferring groups other than amino-acyl groups GO:0001301 6 0.631 146.2 progressive alteration of chromatin during cell aging GO:0015698 9 0.609 140 inorganic anion transport GO:0046527 7 0.604 141.9 glucosyltransferase activity GO:0009415 8 0.603 140.2 response to water GO:0009414 8 0.603 140.2 response to water deprivation GO:0009269 8 0.603 140.2 response to dessication GO:0000096 19 0.602 133.6 sulfur amino acid metabolism GO:0006325 102 0.596 126.8 establishment and/or maintenance of chromatin architecture GO:0006323 102 0.596 126.8 DNA packaging GO:0007243 12 0.596 136.2 protein kinase cascade GO:0003925 20 0.58 132.8 small monomeric GTPase activity GO:0016830 13 0.576 135.5 carbon-carbon lyase activity GO:0009892 7 0.574 140 negative regulation of metabolism GO:0005740 105 0.572 126.7 mitochondrial membrane GO:0007166 21 0.567 132.1 cell surface receptor linked signal transduction GO:0019898 15 0.56 133.5 extrinsic to membrane GO:0016836 16 0.555 134.8 hydro-lyase activity GO:0006767 36 0.554 129.5 water-soluble vitamin metabolism GO:0006766 36 0.554 129.5 vitamin metabolism GO:0005773 100 0.554 126.2 vacuole GO:0016575 8 0.54 138.5 histone deacetylation GO:0006353 8 0.54 138.4 transcription termination GO:0006303 10 0.537 137.1 double-strand break repair via nonhomologous end-joining GO:0008565 25 0.525 130.2 protein transporter activity GO:0015837 26 0.524 131 amine/polyamine transport GO:0009206 12 0.519 134.8 purine ribonucleoside triphosphate biosynthesis GO:0009205 12 0.519 134.8 purine ribonucleoside triphosphate metabolism GO:0009201 12 0.519 134.8 ribonucleoside triphosphate biosynthesis GO:0009199 12 0.519 134.8 ribonucleoside triphosphate metabolism GO:0009145 12 0.519 134.8 purine nucleoside triphosphate biosynthesis GO:0009144 12 0.519 134.8 purine nucleoside triphosphate metabolism GO:0009142 12 0.519 134.8 nucleoside triphosphate biosynthesis GO:0000910 40 0.509 128.1 cytokinesis GO:0004536 11 0.489 134.8 deoxyribonuclease activity GO:0006616 7 0.485 137.7 SRP-dependent cotranslational membrane targeting, translocation GO:0007001 114 0.475 125.2 chromosome organization and biogenesis (sensu Eukarya) GO:0030466 13 0.458 132.2 chromatin silencing at silent mating-type cassettes (sensu Fungi) GO:0006347 13 0.458 132.2 chromatin silencing at HML and HMR (sensu Saccharomyces) GO:0045263 8 0.446 135.1 proton-transporting ATP synthase complex, coupling factor F(o) GO:0000276 8 0.446 135.1 proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukarya) GO:0004840 9 0.446 135.6 ubiquitin conjugating enzyme activity GO:0030473 6 0.442 139.7 nuclear migration (sensu Fungi) GO:0000065 6 0.442 139.7 nuclear migration (sensu Saccharomyces) GO:0000165 10 0.431 134.4 MAPKKK cascade GO:0016757 60 0.428 126.7 transferase activity, transferring glycosyl groups GO:0007234 7 0.425 135 osmosensory signaling pathway via two-component system GO:0000160 7 0.425 135 two-component signal transduction system (phosphorelay) GO:0046873 17 0.419 130.3 metal ion transporter activity GO:0045277 6 0.415 138.2 respiratory chain complex IV GO:0016676 6 0.415 138.2 oxidoreductase activity, acting on heme group of donors, oxygen as acceptor GO:0016675 6 0.415 138.2 oxidoreductase activity, acting on heme group of donors GO:0015002 6 0.415 138.2 heme-copper terminal oxidase activity GO:0005751 6 0.415 138.2 respiratory chain complex IV (sensu Eukarya) GO:0004129 6 0.415 138.2 cytochrome-c oxidase activity GO:0006997 141 0.41 124.2 nuclear organization and biogenesis GO:0016023 56 0.397 126.5 cytoplasmic vesicle GO:0030864 37 0.395 126.2 cortical actin cytoskeleton GO:0030863 37 0.395 126.2 cortical cytoskeleton GO:0009607 30 0.395 127.6 response to biotic stimulus GO:0009141 13 0.38 130.8 nucleoside triphosphate metabolism GO:0006109 13 0.38 130.8 regulation of carbohydrate metabolism GO:0030479 21 0.367 128.6 actin cortical patch (sensu Fungi) GO:0005857 21 0.367 128.6 actin cortical patch (sensu Saccharomyces) GO:0003924 34 0.363 126.4 GTPase activity GO:0008374 6 0.361 136.2 O-acyltransferase activity GO:0008639 10 0.36 132.7 small protein conjugating enzyme activity GO:0005795 10 0.36 132.3 Golgi stack GO:0009987 1339 0.352 122.4 cellular process GO:0008152 1726 0.352 122.1 metabolism GO:0008151 1286 0.352 122.4 cell growth and/or maintenance GO:0019954 47 0.345 126.8 asexual reproduction GO:0007114 47 0.345 126.8 budding GO:0042578 55 0.341 126 phosphoric ester hydrolase activity GO:0006057 7 0.336 132.1 mannoprotein biosynthesis GO:0006056 7 0.336 132.1 mannoprotein metabolism GO:0000032 7 0.336 132.1 cell wall mannoprotein biosynthesis GO:0016746 52 0.33 125.2 transferase activity, transferring acyl groups GO:0016485 12 0.328 129 protein processing GO:0045814 37 0.326 125.3 negative regulation of gene expression, epigenetic GO:0006342 37 0.326 125.3 chromatin silencing GO:0003773 10 0.325 131.6 heat shock protein activity GO:0015082 17 0.323 128.5 di-, tri-valent inorganic cation transporter activity GO:0009167 6 0.307 134.3 purine ribonucleoside monophosphate metabolism GO:0009161 6 0.307 134.3 ribonucleoside monophosphate metabolism GO:0005938 62 0.305 124.8 cell cortex GO:0016021 112 0.302 124.5 integral to membrane GO:0016791 51 0.297 125.5 phosphoric monoester hydrolase activity GO:0046916 20 0.276 126.7 transition metal ion homeostasis GO:0042364 17 0.275 127.2 water-soluble vitamin biosynthesis GO:0009110 17 0.275 127.2 vitamin biosynthesis GO:0005096 24 0.275 127.9 GTPase activator activity GO:0000288 13 0.262 127.5 mRNA catabolism, deadenylation-dependent GO:0009126 7 0.247 129.9 purine nucleoside monophosphate metabolism GO:0009123 7 0.247 129.9 nucleoside monophosphate metabolism GO:0005342 27 0.234 125 organic acid transporter activity GO:0030695 40 0.233 124 GTPase regulator activity GO:0006614 8 0.227 128.9 SRP-dependent cotranslational membrane targeting GO:0016835 20 0.226 125 carbon-oxygen lyase activity GO:0006351 349 0.225 122.8 transcription, DNA-dependent GO:0030005 24 0.224 126.2 di-, tri-valent inorganic cation homeostasis GO:0030363 10 0.219 128.6 pre-mRNA cleavage factor activity GO:0009069 10 0.219 128.9 serine family amino acid metabolism GO:0007155 7 0.217 128 cell adhesion GO:0000278 188 0.215 122.4 mitotic cell cycle GO:0000118 16 0.207 126.8 histone deacetylase complex GO:0006476 11 0.203 126.3 protein amino acid deacetylation GO:0016780 6 0.2 130 phosphotransferase activity, for other substituted phosphate groups GO:0046943 25 0.191 124.9 carboxylic acid transporter activity GO:0030150 13 0.184 125.2 mitochondrial matrix protein import GO:0042273 10 0.184 127.3 ribosomal large subunit biogenesis GO:0003928 6 0.173 129.3 RAB small monomeric GTPase activity GO:0006643 60 0.171 123.4 membrane lipid metabolism GO:0007094 8 0.164 126.8 mitotic spindle checkpoint GO:0006732 66 0.162 123.1 coenzyme metabolism GO:0019897 7 0.157 126.4 extrinsic to plasma membrane GO:0016829 44 0.157 123.6 lyase activity GO:0008047 44 0.157 123.8 enzyme activator activity GO:0006493 9 0.151 126.9 O-linked glycosylation GO:0006369 7 0.128 125 transcription termination from Pol II promoter GO:0030135 47 0.125 123.6 coated vesicle GO:0030015 6 0.119 127.2 CCR4-NOT core complex GO:0000289 6 0.119 127.2 poly(A) tail shortening GO:0009889 10 0.113 125.4 regulation of biosynthesis GO:0007105 10 0.113 125.8 cytokinesis, site selection GO:0000282 10 0.113 125.8 bud site selection GO:0030138 13 0.106 123.3 COPII-coated vesicle GO:0006879 13 0.106 123.5 iron ion homeostasis GO:0008415 42 0.104 122.6 acyltransferase activity GO:0007531 8 0.101 124.5 mating-type determination GO:0007530 8 0.101 124.5 sex determination GO:0007097 8 0.101 124.9 nuclear migration GO:0046034 11 0.095 123.5 ATP metabolism GO:0045259 11 0.095 123.5 proton-transporting ATP synthase complex GO:0045255 11 0.095 123.5 hydrogen-translocating F-type ATPase complex GO:0016469 11 0.095 123.5 proton-transporting two-sector ATPase complex GO:0015986 11 0.095 123.5 ATP synthesis coupled proton transport GO:0015985 11 0.095 123.5 energy coupled proton transport, down the electrochemical gradient GO:0006754 11 0.095 123.5 ATP biosynthesis GO:0006753 11 0.095 123.5 nucleoside phosphate metabolism GO:0005753 11 0.095 123.5 proton-transporting ATP synthase complex (sensu Eukarya) GO:0016282 25 0.08 122.5 eukaryotic 43S preinitiation complex GO:0030478 16 0.076 123 actin cap (sensu Fungi) GO:0000143 16 0.076 123 actin cap (sensu Saccharomyces) GO:0045896 8 0.07 123.4 regulation of transcription, mitotic GO:0007068 8 0.07 123.4 negative regulation of transcription, mitotic GO:0005849 6 0.065 125.8 mRNA cleavage factor complex GO:0006612 12 0.06 122.1 protein-membrane targeting GO:0005625 18 0.049 121.6 soluble fraction GO:0006111 7 0.038 122.4 regulation of gluconeogenesis GO:0045912 6 0.038 124.5 negative regulation of carbohydrate metabolism GO:0045721 6 0.038 124.5 negative regulation of gluconeogenesis GO:0009890 6 0.038 124.5 negative regulation of biosynthesis GO:0009056 182 0.021 121.8 catabolism GO:0046942 24 0.018 122.8 carboxylic acid transport GO:0015849 24 0.018 122.8 organic acid transport GO:0009605 133 0.01 121.1 response to external stimulus GO:0005737 1896 0.003 121.4 cytoplasm GO:0005623 2869 0.003 121.5 cell GO:0003674 3253 0.003 121 molecular_function GO:0019213 14 -0.006 121 deacetylase activity GO:0046933 9 -0.013 121.2 hydrogen-transporting ATP synthase activity, rotational mechanism GO:0016779 48 -0.014 121.1 nucleotidyltransferase activity GO:0006378 15 -0.015 120.1 mRNA polyadenylation GO:0006388 6 -0.016 122.5 tRNA splicing GO:0000394 6 -0.016 122.5 RNA splicing, via endonucleolytic cleavage and ligation GO:0000139 12 -0.017 120.9 Golgi membrane GO:0030866 8 -0.024 120.5 cortical actin cytoskeleton organization and biogenesis GO:0030865 8 -0.024 120.5 cortical cytoskeleton organization and biogenesis GO:0000147 8 -0.024 120.5 actin cortical patch assembly GO:0000030 26 -0.024 120.6 mannosyltransferase activity GO:0006800 25 -0.031 120.4 oxygen and reactive oxygen species metabolism GO:0016458 41 -0.04 121.4 gene silencing GO:0016440 41 -0.04 121.4 transcriptional gene silencing GO:0006740 6 -0.043 121.8 NADPH regeneration GO:0000726 19 -0.043 120.2 non-recombinational repair GO:0016579 12 -0.055 119.4 protein deubiquitination GO:0005736 12 -0.055 119.8 DNA-directed RNA polymerase I complex GO:0001302 12 -0.055 119.5 replicative cell aging GO:0008643 7 -0.081 118.4 carbohydrate transport GO:0006379 11 -0.084 118.5 mRNA cleavage GO:0018193 7 -0.11 117.4 peptidyl-amino acid modification GO:0009628 105 -0.118 120.8 response to abiotic stimulus GO:0006464 243 -0.136 120.3 protein modification GO:0000324 75 -0.142 120.5 vacuole (sensu Fungi) GO:0000323 75 -0.142 120.5 lytic vacuole GO:0000322 75 -0.142 120.5 storage vacuole GO:0030119 8 -0.149 116.9 membrane coat adaptor complex GO:0007118 8 -0.149 116.6 apical bud growth GO:0030014 11 -0.156 116.8 CCR4-NOT complex GO:0007186 13 -0.169 116 G-protein coupled receptor protein signaling pathway GO:0016758 48 -0.173 119.4 transferase activity, transferring hexosyl groups GO:0030364 9 -0.177 116.9 cleavage/polyadenylation specificity factor activity GO:0006525 9 -0.177 116.7 arginine metabolism GO:0000051 9 -0.177 116.7 urea cycle intermediate metabolism GO:0015674 20 -0.179 117 di-, tri-valent inorganic cation transport GO:0046467 46 -0.181 119.8 membrane lipid biosynthesis GO:0008289 11 -0.191 115.2 lipid binding GO:0009108 34 -0.201 117.2 coenzyme biosynthesis GO:0004520 10 -0.206 116.9 endodeoxyribonuclease activity GO:0005666 9 -0.21 115.8 DNA-directed RNA polymerase III complex GO:0016866 8 -0.212 114.9 intramolecular transferase activity GO:0016831 7 -0.23 113.3 carboxy-lyase activity GO:0016887 89 -0.231 119.3 ATPase activity GO:0004620 6 -0.231 114.7 phospholipase activity GO:0016818 137 -0.239 119.8 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0016817 137 -0.239 119.8 hydrolase activity, acting on acid anhydrides GO:0005665 10 -0.241 115 DNA-directed RNA polymerase II, core complex GO:0000267 53 -0.242 119.5 cell fraction GO:0006810 444 -0.252 120.9 transport GO:0006897 27 -0.273 116.3 endocytosis GO:0000243 8 -0.275 112.2 commitment complex GO:0001510 10 -0.276 114.4 RNA methylation GO:0008033 17 -0.3 115.7 tRNA processing GO:0007010 155 -0.316 119.7 cytoskeleton organization and biogenesis GO:0000003 94 -0.331 118.5 reproduction GO:0015144 8 -0.338 110.6 carbohydrate transporter activity GO:0003777 6 -0.339 110 microtubule motor activity GO:0005732 19 -0.341 114.3 small nucleolar ribonucleoprotein complex GO:0008150 3254 -0.347 121 biological_process GO:0005575 3254 -0.347 121 cellular_component GO:0003673 3254 -0.347 121 Gene_Ontology GO:0015171 17 -0.348 114.4 amino acid transporter activity GO:0005624 36 -0.359 116.2 membrane fraction GO:0008094 12 -0.362 111.3 DNA dependent ATPase activity GO:0004843 12 -0.362 111.3 ubiquitin-specific protease activity GO:0016645 8 -0.369 109.5 oxidoreductase activity, acting on the CH-NH group of donors GO:0008213 8 -0.369 109.8 protein amino acid alkylation GO:0006479 8 -0.369 109.8 protein amino acid methylation GO:0016646 7 -0.378 108.3 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor GO:0006606 32 -0.379 114.8 protein-nucleus import GO:0003779 10 -0.382 111.7 actin binding GO:0006457 28 -0.392 115.7 protein folding GO:0000742 6 -0.393 108.3 karyogamy during conjugation with cellular fusion GO:0016283 22 -0.394 114 eukaryotic 48S initiation complex GO:0005843 22 -0.394 114 cytosolic small ribosomal subunit (sensu Eukarya) GO:0005685 8 -0.4 108 snRNP U1 GO:0000750 9 -0.407 109.4 signal transduction during conjugation with cellular fusion GO:0006650 26 -0.408 113.8 glycerophospholipid metabolism GO:0045003 7 -0.408 107.3 double-strand break repair via synthesis-dependent strand annealing GO:0005770 7 -0.408 107.9 late endosome GO:0004003 7 -0.408 107.9 ATP dependent DNA helicase activity GO:0030474 6 -0.42 107 spindle pole body duplication (sensu Fungi) GO:0015071 6 -0.42 107.5 protein phosphatase type 2C activity GO:0007103 6 -0.42 107 spindle pole body duplication (sensu Saccharomyces) GO:0006301 6 -0.42 107 postreplication repair GO:0006383 20 -0.432 113 transcription from Pol III promoter GO:0030001 21 -0.433 112.3 metal ion transport GO:0016573 21 -0.433 112.6 histone acetylation GO:0006739 7 -0.438 106.7 NADPH metabolism GO:0046915 11 -0.442 108.5 transition metal ion transporter activity GO:0004857 11 -0.442 108.5 enzyme inhibitor activity GO:0006893 13 -0.443 109.1 Golgi to plasma membrane transport GO:0008234 17 -0.444 112 cysteine-type peptidase activity GO:0006944 22 -0.446 112.3 membrane fusion GO:0007126 67 -0.447 116.4 meiosis GO:0015149 6 -0.447 106.3 hexose transporter activity GO:0015145 6 -0.447 106.3 monosaccharide transporter activity GO:0005759 84 -0.451 116.2 mitochondrial matrix GO:0016814 11 -0.478 107.9 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GO:0000152 11 -0.478 107.4 nuclear ubiquitin ligase complex GO:0000041 14 -0.493 109.8 transition metal ion transport GO:0005515 150 -0.495 118 protein binding GO:0006979 22 -0.497 111.4 response to oxidative stress GO:0006526 7 -0.497 104.7 arginine biosynthesis GO:0003676 272 -0.501 118.7 nucleic acid binding GO:0005667 86 -0.524 116.9 transcription factor complex GO:0005057 8 -0.526 104.9 receptor signaling protein activity GO:0006409 18 -0.526 109.4 tRNA-nucleus export GO:0004702 6 -0.528 103.2 receptor signaling protein serine/threonine kinase activity GO:0006302 24 -0.546 111.1 double-strand break repair GO:0000109 12 -0.553 106.2 nucleotide excision repair complex GO:0016407 27 -0.554 111.6 acetyltransferase activity GO:0007534 7 -0.557 102.1 gene conversion at MAT locus GO:0007533 7 -0.557 102.1 mating-type switching/recombination GO:0003684 7 -0.557 102.3 damaged DNA binding GO:0016043 721 -0.574 119.6 cell organization and biogenesis GO:0030481 6 -0.582 101.7 septin ring (sensu Fungi) GO:0000144 6 -0.582 101.7 septin ring (sensu Saccharomyces) GO:0005085 11 -0.586 104.5 guanyl-nucleotide exchange factor activity GO:0019843 7 -0.587 101 rRNA binding GO:0000741 8 -0.588 102.5 karyogamy GO:0000740 8 -0.588 102.5 nuclear membrane fusion GO:0007062 15 -0.59 107.5 sister chromatid cohesion GO:0009101 45 -0.598 113.7 glycoprotein biosynthesis GO:0006486 45 -0.598 113.7 protein amino acid glycosylation GO:0006267 7 -0.616 100.6 pre-replicative complex formation and maintenance GO:0005847 10 -0.63 104 mRNA cleavage and polyadenylation specificity factor complex GO:0000154 10 -0.63 104.5 rRNA modification GO:0016570 38 -0.633 112.6 histone modification GO:0016569 38 -0.633 112.6 covalent chromatin modification GO:0030261 20 -0.634 108 chromosome condensation GO:0000136 6 -0.662 98.3 mannosyltransferase complex GO:0045002 9 -0.669 101.3 double-strand break repair via single-strand annealing GO:0015629 64 -0.683 113.2 actin cytoskeleton GO:0000070 20 -0.685 107.3 mitotic chromosome segregation GO:0045454 6 -0.689 97.3 cell redox homeostasis GO:0030503 6 -0.689 97.3 regulation of redox homeostasis GO:0005730 122 -0.694 116 nucleolus GO:0005622 2654 -0.696 119.7 intracellular GO:0006487 32 -0.698 109.9 N-linked glycosylation GO:0006626 24 -0.7 108.7 protein-mitochondrial targeting GO:0005782 10 -0.701 102.7 peroxisomal matrix GO:0000054 10 -0.701 102.2 ribosome-nucleus export GO:0042144 9 -0.702 100.6 vacuole fusion (non-autophagic) GO:0019953 51 -0.704 112.1 sexual reproduction GO:0000747 51 -0.704 112.1 conjugation with cellular fusion GO:0000746 51 -0.704 112.1 conjugation GO:0005840 116 -0.71 115.2 ribosome GO:0007119 6 -0.716 96.8 isotropic bud growth GO:0006730 6 -0.716 96.8 one-carbon compound metabolism GO:0006865 18 -0.717 105.8 amino acid transport GO:0006610 18 -0.717 105.3 ribosomal protein-nucleus import GO:0006608 18 -0.717 105.3 snRNP protein-nucleus import GO:0006607 18 -0.717 105.3 NLS-bearing substrate-nucleus import GO:0006408 18 -0.717 105.3 snRNA-nucleus export GO:0000301 9 -0.734 99.4 retrograde (vesicle recycling within Golgi) transport GO:0016846 7 -0.736 96.7 carbon-sulfur lyase activity GO:0006743 7 -0.736 96.3 ubiquinone metabolism GO:0030433 10 -0.736 101.8 ER-associated protein catabolism GO:0006473 26 -0.737 107.8 protein amino acid acetylation GO:0000027 23 -0.741 106.6 ribosomal large subunit assembly and maintenance GO:0009063 6 -0.743 95.3 amino acid catabolism GO:0005543 8 -0.745 97.1 phospholipid binding GO:0007121 22 -0.752 106 polar budding GO:0000723 13 -0.757 101.4 telomere maintenance GO:0006268 7 -0.765 95.9 DNA unwinding GO:0004725 7 -0.765 95.4 protein tyrosine phosphatase activity GO:0015268 6 -0.77 94.7 alpha-type channel activity GO:0015267 6 -0.77 94.7 channel/pore class transporter activity GO:0007030 6 -0.77 94.5 Golgi organization and biogenesis GO:0030480 17 -0.779 105.7 contractile ring (sensu Fungi) GO:0005826 17 -0.779 105.7 contractile ring GO:0000142 17 -0.779 105.7 contractile ring (sensu Saccharomyces) GO:0016072 12 -0.783 100.7 rRNA metabolism GO:0009100 46 -0.797 111.8 glycoprotein metabolism GO:0000784 11 -0.8 98.9 nuclear chromosome, telomeric region GO:0000781 11 -0.8 98.9 chromosome, telomeric region GO:0003767 10 -0.807 99 co-chaperone activity GO:0005830 48 -0.81 111.1 cytosolic ribosome (sensu Eukarya) GO:0004402 12 -0.821 99.8 histone acetyltransferase activity GO:0030677 6 -0.824 92 ribonuclease P complex GO:0006269 6 -0.824 92.2 DNA replication, priming GO:0005655 6 -0.824 92 nucleolar ribonuclease P complex GO:0004526 6 -0.824 92 ribonuclease P activity GO:0006270 17 -0.827 104.7 DNA replication initiation GO:0005842 21 -0.833 104.9 cytosolic large ribosomal subunit (sensu Eukarya) GO:0030176 13 -0.835 99.4 integral to endoplasmic reticulum membrane GO:0000245 11 -0.836 97.5 spliceosome assembly GO:0005885 6 -0.851 91.8 Arp2/3 protein complex GO:0000124 14 -0.858 100.6 SAGA complex GO:0016891 12 -0.86 98.4 endoribonuclease activity, producing 5'-phosphomonoesters GO:0030488 9 -0.866 95.8 tRNA methylation GO:0008238 11 -0.872 96.9 exopeptidase activity GO:0016810 39 -0.875 109.7 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0019774 6 -0.878 90.3 proteasome core complex, beta-subunit complex (sensu Eukarya) GO:0005658 6 -0.878 90.5 alpha DNA polymerase:primase complex GO:0000087 78 -0.882 112 M phase of mitotic cell cycle GO:0003887 16 -0.882 101.2 DNA-directed DNA polymerase activity GO:0004386 48 -0.89 110.4 helicase activity GO:0000123 32 -0.89 106.5 histone acetyltransferase complex GO:0000084 68 -0.89 111.4 S phase of mitotic cell cycle GO:0005816 34 -0.891 106.4 spindle pole body GO:0005815 34 -0.891 106.4 microtubule organizing center GO:0012505 128 -0.893 114.9 endomembrane system GO:0003724 29 -0.898 106.8 RNA helicase activity GO:0006333 12 -0.898 97.8 chromatin assembly/disassembly GO:0005488 462 -0.899 117.4 binding GO:0016811 23 -0.901 103.9 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016071 49 -0.901 109.2 mRNA metabolism GO:0003682 13 -0.913 97.9 chromatin binding GO:0000922 37 -0.916 107.7 spindle pole GO:0006260 67 -0.921 111.3 DNA replication GO:0042221 25 -0.921 104.4 response to chemical substance GO:0008186 19 -0.937 102 RNA dependent ATPase activity GO:0006289 19 -0.937 102.8 nucleotide-excision repair GO:0004004 19 -0.937 102 ATP dependent RNA helicase activity GO:0000749 20 -0.938 102.8 response to pheromone during conjugation with cellular fusion GO:0006515 11 -0.944 94.8 misfolded or incompletely synthesized protein catabolism GO:0000172 7 -0.944 89 ribonuclease MRP complex GO:0000171 7 -0.944 89 ribonuclease MRP activity GO:0042277 10 -0.948 95.9 peptide binding GO:0016860 10 -0.948 95.9 intramolecular isomerase activity GO:0005048 10 -0.948 95.9 signal sequence binding GO:0006418 18 -0.957 100.1 amino acid activation GO:0042054 6 -0.959 87.5 histone methyltransferase activity GO:0018024 6 -0.959 87.5 histone-lysine N-methyltransferase activity GO:0016571 6 -0.959 87.5 histone methylation GO:0000727 6 -0.959 87.8 double-strand break repair via break-induced replication GO:0046021 7 -0.974 88.3 regulation of transcription from Pol II promoter, mitotic GO:0007070 7 -0.974 88.3 negative regulation of transcription from Pol II promoter, mitotic GO:0005675 7 -0.974 88.3 transcription factor TFIIH complex GO:0015935 42 -0.985 107.4 small ribosomal subunit GO:0006365 37 -0.985 106.9 35S primary transcript processing GO:0006999 20 -0.988 101.2 nuclear pore organization and biogenesis GO:0005663 8 -0.996 89.2 DNA replication factor C complex GO:0008283 361 -1.002 116.9 cell proliferation GO:0004549 7 -1.003 87.1 tRNA-specific ribonuclease activity GO:0008026 27 -1.004 103.7 ATP dependent helicase activity GO:0007034 24 -1.007 102.4 vacuolar transport GO:0003774 11 -1.015 92.3 motor activity GO:0005874 17 -1.019 100.5 microtubule GO:0005844 8 -1.027 88.4 polysome GO:0000011 9 -1.029 90 vacuole inheritance GO:0016298 13 -1.031 94.8 lipase activity GO:0006752 25 -1.032 102.6 group transfer coenzyme metabolism GO:0019239 7 -1.033 86.7 deaminase activity GO:0008250 7 -1.033 86.9 oligosaccharyl transferase complex GO:0004579 7 -1.033 86.9 dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity GO:0004576 7 -1.033 86.9 oligosaccharyl transferase activity GO:0005763 20 -1.039 100.2 mitochondrial small ribosomal subunit GO:0000314 20 -1.039 100.2 organellar small ribosomal subunit GO:0017119 6 -1.04 84.3 Golgi transport complex GO:0000725 12 -1.051 93.2 recombinational repair GO:0000724 12 -1.051 93.2 double-strand break repair via homologous recombination GO:0006272 11 -1.051 91.3 leading strand elongation GO:0016462 7 -1.063 85.3 pyrophosphatase activity GO:0006888 41 -1.066 107.1 ER to Golgi transport GO:0042257 26 -1.066 101.3 ribosomal subunit assembly GO:0007067 77 -1.076 110.7 mitosis GO:0003678 15 -1.077 96.7 DNA helicase activity GO:0016896 21 -1.083 99 exoribonuclease activity, producing 5'-phosphomonoesters GO:0004532 21 -1.083 99 exoribonuclease activity GO:0009310 7 -1.093 84 amine catabolism GO:0000329 30 -1.102 102.8 vacuolar membrane (sensu Fungi) GO:0030435 53 -1.113 108.7 sporulation GO:0006259 242 -1.114 115.2 DNA metabolism GO:0008175 10 -1.125 90.7 tRNA methyltransferase activity GO:0000022 9 -1.128 87.3 mitotic spindle elongation GO:0006609 20 -1.14 98 mRNA-binding (hnRNP) protein-nucleus import GO:0042493 16 -1.143 95.9 response to drug GO:0008092 29 -1.144 103 cytoskeletal protein binding GO:0009593 32 -1.145 102.1 perception of chemical substance GO:0009582 32 -1.145 102.1 perception of abiotic stimulus GO:0009581 32 -1.145 102.1 perception of external stimulus GO:0007606 32 -1.145 102.1 chemosensory perception GO:0007600 32 -1.145 102.1 sensory perception GO:0008298 6 -1.147 80.3 mRNA localization, intracellular GO:0005686 7 -1.152 82.9 snRNP U2 GO:0000092 7 -1.152 82.3 mitotic anaphase B GO:0009719 105 -1.153 111.9 response to endogenous stimulus GO:0042579 31 -1.157 102.8 microbody GO:0005777 31 -1.157 102.8 peroxisome GO:0046474 22 -1.16 98.4 glycerophospholipid biosynthesis GO:0016886 22 -1.16 98.3 ligase activity, forming phosphoric ester bonds GO:0016876 22 -1.16 98.3 ligase activity, forming aminoacyl-tRNA and related compounds GO:0016875 22 -1.16 98.3 ligase activity, forming carbon-oxygen bonds GO:0008452 22 -1.16 98.3 RNA ligase activity GO:0004812 22 -1.16 98.3 tRNA ligase activity GO:0019236 30 -1.162 101.3 response to pheromone GO:0005485 6 -1.174 79 v-SNARE activity GO:0016197 16 -1.186 94.1 endosome transport GO:0007032 16 -1.186 94.1 endosome organization and biogenesis GO:0016410 9 -1.193 85.1 N-acyltransferase activity GO:0008080 9 -1.193 85.1 N-acetyltransferase activity GO:0006974 102 -1.196 110.3 response to DNA damage stimulus GO:0008372 369 -1.201 115.7 cellular_component unknown GO:0015940 6 -1.201 78.8 pantothenate biosynthesis GO:0015939 6 -1.201 78.8 pantothenate metabolism GO:0006644 42 -1.202 104.5 phospholipid metabolism GO:0005875 12 -1.204 89.4 microtubule associated complex GO:0006402 32 -1.209 101.8 mRNA catabolism GO:0000001 9 -1.226 84.2 mitochondrion inheritance GO:0000090 26 -1.23 98.4 mitotic anaphase GO:0016251 39 -1.232 104.5 general RNA polymerase II transcription factor activity GO:0015931 46 -1.259 105.5 nucleobase, nucleoside, nucleotide and nucleic acid transport GO:0007152 14 -1.264 90.1 spore wall assembly (sensu Saccharomyces) GO:0008237 11 -1.266 85.7 metallopeptidase activity GO:0030437 47 -1.268 104.3 sporulation (sensu Fungi) GO:0016279 7 -1.271 78.1 protein-lysine N-methyltransferase activity GO:0016278 7 -1.271 78.1 lysine N-methyltransferase activity GO:0008054 7 -1.271 78.4 cyclin catabolism GO:0007151 42 -1.275 103.6 sporulation (sensu Saccharomyces) GO:0045324 8 -1.278 80.6 late endosome to vacuole transport GO:0004177 8 -1.278 80.1 aminopeptidase activity GO:0006273 12 -1.281 87.2 lagging strand elongation GO:0004519 30 -1.281 99.4 endonuclease activity GO:0005838 18 -1.293 93.6 proteasome regulatory particle (sensu Eukarya) GO:0016859 7 -1.301 77.9 cis-trans isomerase activity GO:0003755 7 -1.301 77.9 peptidyl-prolyl cis-trans isomerase activity GO:0000002 13 -1.305 87.4 mitochondrial genome maintenance GO:0030384 17 -1.307 94.2 phosphoinositide metabolism GO:0006271 23 -1.328 95.1 DNA strand elongation GO:0006401 37 -1.33 101.8 RNA catabolism GO:0005654 196 -1.332 112.5 nucleoplasm GO:0000300 6 -1.336 73.3 peripheral to membrane of membrane fraction GO:0008276 10 -1.337 84.7 protein methyltransferase activity GO:0030136 20 -1.342 94.7 clathrin-coated vesicle GO:0008173 15 -1.342 90.3 RNA methyltransferase activity GO:0016192 145 -1.351 111.7 vesicle-mediated transport GO:0007091 9 -1.357 80.3 mitotic metaphase/anaphase transition GO:0007049 318 -1.362 114 cell cycle GO:0006284 6 -1.363 72.3 base-excision repair GO:0000279 146 -1.366 111.2 M phase GO:0030471 24 -1.366 95.9 spindle pole body and microtubule cycle (sensu Fungi) GO:0007102 24 -1.366 95.9 spindle pole body and microtubule cycle (sensu Saccharomyces) GO:0006399 38 -1.383 101.6 tRNA metabolism GO:0000080 14 -1.386 87 G1 phase of mitotic cell cycle GO:0042244 15 -1.387 89.2 spore wall assembly GO:0030476 15 -1.387 89.2 spore wall assembly (sensu Fungi) GO:0003754 54 -1.387 104.9 chaperone activity GO:0045132 6 -1.39 71.5 meiotic chromosome segregation GO:0015631 9 -1.39 79.3 tubulin binding GO:0005635 51 -1.398 103.1 nuclear membrane GO:0005657 27 -1.398 96.7 replication fork GO:0006625 8 -1.404 76.6 protein-peroxisome targeting GO:0008170 16 -1.404 89.8 N-methyltransferase activity GO:0006913 62 -1.417 104.9 nucleocytoplasmic transport GO:0004521 15 -1.431 88.9 endoribonuclease activity GO:0006511 65 -1.433 104.1 ubiquitin-dependent protein catabolism GO:0016789 21 -1.433 92.9 carboxylic ester hydrolase activity GO:0006407 21 -1.433 92.9 rRNA-nucleus export GO:0000114 10 -1.443 81.8 G1-specific transcription in mitotic cell cycle GO:0007021 6 -1.444 69.5 tubulin folding GO:0007005 64 -1.458 104.6 mitochondrion organization and biogenesis GO:0005524 8 -1.466 74.5 ATP binding GO:0016741 54 -1.469 103.6 transferase activity, transferring one-carbon groups GO:0016944 10 -1.479 80.1 Pol II transcription elongation factor activity GO:0005856 126 -1.48 109.3 cytoskeleton GO:0016787 396 -1.481 114.6 hydrolase activity GO:0000226 55 -1.485 103.1 microtubule cytoskeleton organization and biogenesis GO:0008654 33 -1.489 98.8 phospholipid biosynthesis GO:0016684 6 -1.498 67.5 oxidoreductase activity, acting on peroxide as acceptor GO:0005876 11 -1.517 78.2 spindle microtubule GO:0005669 11 -1.517 78.7 transcription factor TFIID complex GO:0006400 22 -1.518 91.4 tRNA modification GO:0045005 15 -1.519 86 maintenance of fidelity during DNA dependent DNA replication GO:0006298 15 -1.519 86 mismatch repair GO:0004527 30 -1.521 95.8 exonuclease activity GO:0006611 31 -1.529 96 protein-nucleus export GO:0006312 19 -1.533 90.8 mitotic recombination GO:0006891 16 -1.535 86.9 intra-Golgi transport GO:0005794 76 -1.539 105.2 Golgi apparatus GO:0006281 84 -1.539 105 DNA repair GO:0009651 10 -1.55 78.9 salinity response GO:0000280 136 -1.552 109.3 nuclear division GO:0005680 8 -1.56 71.5 anaphase-promoting complex GO:0042255 29 -1.576 95.7 ribosome assembly GO:0000175 16 -1.578 85.4 3'-5' exoribonuclease activity GO:0006892 34 -1.58 95.8 post-Golgi transport GO:0046930 31 -1.591 95.5 pore complex GO:0006367 31 -1.591 96 transcription initiation from Pol II promoter GO:0005643 31 -1.591 95.5 nuclear pore GO:0009451 32 -1.592 95.5 RNA modification GO:0042727 7 -1.599 67.1 vitamin B2 and derivative biosynthesis GO:0042726 7 -1.599 67.1 vitamin B2 and derivative metabolism GO:0006384 7 -1.599 67.4 transcription initiation from Pol III promoter GO:0003709 7 -1.599 67.4 RNA polymerase III transcription factor activity GO:0004175 37 -1.606 97.1 endopeptidase activity GO:0000072 37 -1.606 97.6 M-phase specific microtubule process GO:0030163 94 -1.616 106.1 protein catabolism GO:0016455 12 -1.626 78.7 RNA polymerase II transcription mediator activity GO:0008023 12 -1.626 78.3 transcription elongation factor complex GO:0005778 12 -1.626 78.7 peroxisomal membrane GO:0003711 12 -1.626 78.3 transcriptional elongation regulator activity GO:0009231 6 -1.632 62.3 vitamin B2 biosynthesis GO:0006771 6 -1.632 62.3 vitamin B2 metabolism GO:0005819 47 -1.635 99.5 spindle GO:0005684 17 -1.642 87.9 major (U2-dependent) spliceosome GO:0006374 8 -1.655 68.6 nuclear mRNA splicing via U2-type spliceosome GO:0030554 9 -1.685 70.6 adenyl nucleotide binding GO:0006904 8 -1.686 67.4 nonselective vesicle docking GO:0030515 17 -1.69 86.5 snoRNA binding GO:0005739 404 -1.695 114 mitochondrion GO:0016788 131 -1.702 108 hydrolase activity, acting on ester bonds GO:0006360 121 -1.703 107.1 transcription from Pol I promoter GO:0015630 57 -1.717 101.9 microtubule cytoskeleton GO:0005828 8 -1.717 66.2 kinetochore microtubule GO:0007031 24 -1.725 88.9 peroxisome organization and biogenesis GO:0019941 66 -1.737 102.9 modification-dependent protein catabolism GO:0005486 6 -1.74 58.3 t-SNARE activity GO:0016853 29 -1.761 92.4 isomerase activity GO:0000754 6 -1.767 57.3 adaptation to pheromone during conjugation with cellular fusion GO:0005484 11 -1.768 71.4 SNAP receptor activity GO:0015036 8 -1.78 64.9 disulfide oxidoreductase activity GO:0006415 8 -1.78 64.1 translational termination GO:0006139 768 -1.789 115.4 nucleobase, nucleoside, nucleotide and nucleic acid metabolism GO:0005798 6 -1.794 56.3 Golgi vesicle GO:0006368 11 -1.804 70.3 RNA elongation from Pol II promoter GO:0042764 8 -1.811 63.9 prospore GO:0042763 8 -1.811 63.9 immature spore GO:0005628 8 -1.811 63.9 prospore membrane GO:0000177 9 -1.816 66.9 cytoplasmic exosome (RNase complex) GO:0006311 6 -1.821 55.7 meiotic gene conversion GO:0006605 138 -1.832 107.1 protein targeting GO:0008408 21 -1.834 84.8 3'-5' exonuclease activity GO:0008168 52 -1.86 98.3 methyltransferase activity GO:0008233 72 -1.865 101.5 peptidase activity GO:0007017 59 -1.868 98.6 microtubule-based process GO:0000119 14 -1.873 75.4 mediator complex GO:0006886 149 -1.875 107.7 intracellular protein transport GO:0005801 11 -1.875 68.6 Golgi cis-face GO:0006261 54 -1.878 98 DNA dependent DNA replication GO:0006896 13 -1.893 72.4 Golgi to vacuole transport GO:0015031 152 -1.899 107.8 protein transport GO:0030490 31 -1.9 90.3 processing of 20S pre-rRNA GO:0050658 40 -1.901 94 RNA transport GO:0050657 40 -1.901 94 nucleic acid transport GO:0006405 40 -1.901 94 RNA-nucleus export GO:0007051 27 -1.904 87.7 spindle assembly GO:0005839 14 -1.914 74 proteasome core complex (sensu Eukarya) GO:0004540 38 -1.928 93.8 ribonuclease activity GO:0016591 52 -1.941 97.8 DNA-directed RNA polymerase II, holoenzyme GO:0030008 8 -1.968 58.4 TRAPP GO:0007046 123 -1.975 106 ribosome biogenesis GO:0009059 240 -2 111 macromolecule biosynthesis GO:0030472 12 -2.009 68.4 mitotic spindle assembly (sensu Fungi) GO:0000071 12 -2.009 68.4 mitotic spindle assembly (sensu Saccharomyces) GO:0006508 85 -2.024 102.9 proteolysis and peptidolysis GO:0005478 17 -2.026 79.1 intracellular transporter activity GO:0006996 339 -2.037 111.2 organelle organization and biogenesis GO:0007006 9 -2.045 59.3 mitochondrial membrane organization and biogenesis GO:0006364 101 -2.048 102.6 rRNA processing GO:0016044 16 -2.057 74.2 membrane organization and biogenesis GO:0007007 6 -2.063 46.2 inner mitochondrial membrane organization and biogenesis GO:0009057 131 -2.085 104.9 macromolecule catabolism GO:0003729 61 -2.085 96.7 mRNA binding GO:0003723 132 -2.108 105.1 RNA binding GO:0007020 23 -2.128 80.9 microtubule nucleation GO:0048193 88 -2.133 100.7 Golgi vesicle transport GO:0006887 33 -2.144 88.8 exocytosis GO:0045045 125 -2.155 104.5 secretory pathway GO:0006906 18 -2.156 75.7 nonselective vesicle fusion GO:0006352 39 -2.161 91.5 transcription initiation GO:0000176 10 -2.186 60.4 nuclear exosome (RNase complex) GO:0005200 35 -2.189 88.3 structural constituent of cytoskeleton GO:0000502 35 -2.189 88.8 proteasome complex (sensu Eukarya) GO:0004518 56 -2.217 95.2 nuclease activity GO:0006403 47 -2.221 91.6 RNA localization GO:0016194 19 -2.228 76.4 nonselective vesicle exocytosis GO:0006406 36 -2.255 89.1 mRNA-nucleus export GO:0007052 25 -2.255 80.1 mitotic spindle assembly GO:0000178 11 -2.269 57.4 exosome (RNase complex) GO:0006461 33 -2.275 86.7 protein complex assembly GO:0006412 236 -2.28 108.9 protein biosynthesis GO:0000228 80 -2.314 97.1 nuclear chromosome GO:0007059 48 -2.323 92.3 chromosome segregation GO:0008757 36 -2.325 88.9 S-adenosylmethionine-dependent methyltransferase activity GO:0042254 138 -2.36 103.6 ribosome biogenesis and assembly GO:0006623 41 -2.384 89.6 protein-vacuolar targeting GO:0005768 31 -2.395 82.9 endosome GO:0046489 15 -2.404 66.9 phosphoinositide biosynthesis GO:0006506 13 -2.442 58 GPI anchor biosynthesis GO:0006505 13 -2.442 58 GPI anchor metabolism GO:0005634 1109 -2.443 115 nucleus GO:0017076 18 -2.443 69.5 purine nucleotide binding GO:0007131 19 -2.476 71.2 meiotic recombination GO:0042158 19 -2.525 70.2 lipoprotein biosynthesis GO:0042157 19 -2.525 70.2 lipoprotein metabolism GO:0006497 19 -2.525 70.2 protein lipidation GO:0003735 83 -2.533 97.5 structural constituent of ribosome GO:0005762 24 -2.546 72.2 mitochondrial large ribosomal subunit GO:0000315 24 -2.546 72.2 organellar large ribosomal subunit GO:0046907 265 -2.554 106.1 intracellular transport GO:0015934 45 -2.561 87.4 large ribosomal subunit GO:0007033 77 -2.577 95.7 vacuole organization and biogenesis GO:0030532 38 -2.609 83.1 small nuclear ribonucleoprotein complex GO:0005761 45 -2.637 86.2 mitochondrial ribosome GO:0000313 45 -2.637 86.2 organellar ribosome GO:0000166 19 -2.674 67.2 nucleotide binding GO:0005198 162 -2.684 102.6 structural molecule activity GO:0000004 842 -2.699 113.5 biological_process unknown GO:0007127 25 -2.7 73 meiosis I GO:0005694 90 -2.759 96 chromosome GO:0005554 1218 -2.792 113.7 molecular_function unknown GO:0008380 65 -2.798 88.4 RNA splicing GO:0019538 685 -2.799 111.8 protein metabolism GO:0000067 149 -2.818 100.2 DNA replication and chromosome cycle GO:0005681 40 -2.865 79 spliceosome complex GO:0007128 23 -2.875 66.1 meiotic prophase I GO:0007028 475 -2.888 109.2 cytoplasm organization and biogenesis GO:0000778 24 -2.905 65.8 condensed nuclear chromosome kinetochore GO:0000777 24 -2.905 65.8 condensed chromosome kinetochore GO:0000776 30 -2.957 71.3 kinetochore GO:0008248 31 -3.014 72 pre-mRNA splicing factor activity GO:0030529 205 -3.025 102 ribonucleoprotein complex GO:0000780 25 -3.145 64 condensed nuclear chromosome, pericentric region GO:0000779 25 -3.145 64 condensed chromosome, pericentric region GO:0006310 45 -3.165 79.3 DNA recombination GO:0000775 33 -3.258 71.5 chromosome, pericentric region GO:0000375 58 -3.312 83 RNA splicing, via transesterification reactions GO:0000794 38 -3.563 69.3 condensed nuclear chromosome GO:0000793 38 -3.563 69.3 condensed chromosome GO:0006397 79 -3.641 85.6 mRNA processing GO:0000398 55 -3.642 77.3 nuclear mRNA splicing, via spliceosome GO:0000377 55 -3.642 77.3 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0016070 253 -3.776 99 RNA metabolism GO:0006396 220 -4.054 97.9 RNA processing