Genome-wide regulatory complexity in yeast promoters: Separation of functionally conserved and neutral sequence

Chen-Shan Chin, Jeffrey H. Chuang, and Hao Li
Genome Research 15:205-213, 2005

Abstract

To gauge the complexity of gene regulation in yeast, it is essential to know how much promoter sequence is functional. Conservation across species can be a sensitive means of detecting functional sequences, provided that the significance of conservation can be accurately calibrated with the local neutral mutation rate. By analyzing yeast coding and promoter sequences, we find that neutral mutation rates in yeast are uniform genome-wide, in contrast to mammals, where neutral mutation rates vary along chromosomes. We develop an approach that uses this uniform rate to estimate the amount of promoter sequence under purifying selection. This amount is 30%, corresponding to roughly 90 bp for a typical promoter. Furthermore, using a hidden Markov model, we are able to separate each promoter into distinct high and low conservation regions. Known regulatory motifs are strongly biased toward high conservation regions, while low conservation regions have mutation rates similar to that of the neutral background Certain Gene Ontology groupings of genes (e.g., Carbohydrate Metabolism) have large amounts of high conservation sequence, suggesting complexity in their transcriptional regulation. Others (e.g., RNA Processing) have little high conservation sequence and are likely to be simply regulated. The separation of functionally conserved sequence from the neutral background allows us to estimate the complexity of cis-regulation on a genomic scale.

Genome Research Article

Supplementary Materials

Viewing Promoter Alignments

Alignments for individual genes can be viewed by visiting the URL http://genome.ucsf.edu/YeastReg/align/GENEID.html where GENEID is the accession number. For example, to see the alignment for YCL030C (His4), you visit http://genome.ucsf.edu/YeastReg/align/YCL030C.html . This procedure should work for all genes for which we have 4-species alignments of the promoter sequences.

SCer GCAGTCGAACTGACTCTAATAGTGACTCCGGTAAATTAGTTAATTAATTGCTAAACC 
SPar GCAGTCGAACTGACTCTAATAGTGACTCCGGTAAATTAGTTAATTAATTGCTAAACC
SMik GCGGTCAAACTGACTCTAATAGTGACTCCGGTAAATTAGTTAATTAATTGCTAAACC
SBay -TGAACGAACTGACTCTAATAGTGACTCTGGTAAATTAGTTAATTAATTTCTAAACC
          * ********************* ******************** *******
      ______**************************************************

A small section of a promoter alignment is shown above, as an example. The aligned promoter sequences for each species -- S. cerevisiae, S. paradoxus, S. mikatae, and S. bayanus -- are on the first 4 lines. The first line of *'s indicates positions in which the same base is shared among all 4 species. The second line of *'s and _'s shows the high conservation and low conservation regions inferred by a hidden Markov model, respectively. Blank positions indicate the location of gaps (one occurs in the 1st character of the sequence).

Gene Ontology Categories

Gene Ontology categories differ in the amounts of high conservation sequence in their gene promoters. For each Gene Ontology category, we have quantified the length of highly conserved promoter sequence by measuring a z-score Zl. Higher values of Zl indicate larger amounts of highly conserved sequence.

Acc = Gene Ontology Category Accession ID
Ng = Number of Genes
Zl = z-score for the length of HCR regions in this Gene Ontology category
AveLen = average length of HCR regions in this Gene Ontology category
Term = description

          Acc   Ng     Zl AveLen Term
1 GO0008202 25 +7.142 249.0 steroid metabolism
2 GO0006066 84 +7.070 192.3 alcohol metabolism
3 GO0016126 20 +6.700 253.6 sterol biosynthesis
4 GO0016125 20 +6.700 253.6 sterol metabolism
5 GO0006694 24 +6.635 251.1 steroid biosynthesis
6 GO0008204 18 +6.041 246.4 ergosterol metabolism
7 GO0006696 18 +6.041 246.4 ergosterol biosynthesis
8 GO0006096 12 +5.919 275.8 glycolysis
9 GO0046365 15 +5.823 252.7 monosaccharide catabolism
10 GO0019320 15 +5.823 252.7 hexose catabolism
11 GO0006007 15 +5.823 252.7 glucose catabolism
12 GO0016052 23 +5.608 225.7 carbohydrate catabolism
13 GO0046164 17 +5.357 233.6 alcohol catabolism
14 GO0005975 107 +5.207 165.6 carbohydrate metabolism
15 GO0006006 33 +5.194 200.5 glucose metabolism
16 GO0019318 45 +4.988 187.6 hexose metabolism
17 GO0015980 103 +4.713 163.3 energy derivation by oxidation of organic compounds
18 GO0006091 103 +4.713 163.3 energy pathways
19 GO0016772 191 +4.697 151.3 transferase activity, transferring phosphorus-containing groups
20 GO0016773 121 +4.668 160.6 phosphotransferase activity, alcohol group as acceptor
21 GO0016301 142 +4.654 157.6 kinase activity
22 GO0030312 40 +4.639 188.3 external encapsulating structure
23 GO0009277 40 +4.639 188.3 cell wall (sensu Fungi)
24 GO0005618 40 +4.639 188.3 cell wall
25 GO0006092 39 +4.339 182.6 main pathways of carbohydrate metabolism
26 GO0006629 121 +4.187 156.4 lipid metabolism
27 GO0005996 50 +4.180 177.5 monosaccharide metabolism
28 GO0016564 11 +4.180 237.6 transcriptional repressor activity
29 GO0009653 70 +4.131 166.9 morphogenesis
30 GO0000902 70 +4.131 166.9 cellular morphogenesis
31 GO0019200 11 +4.108 235.9 carbohydrate kinase activity
32 GO0040007 47 +4.012 176.6 growth
33 GO0016538 15 +4.010 211.9 cyclin-dependent protein kinase, intrinsic regulator activity
34 GO0030447 46 +3.980 174.0 filamentous growth
35 GO0007150 46 +3.980 174.0 growth pattern
36 GO0016491 122 +3.977 152.9 oxidoreductase activity
37 GO0004674 60 +3.943 167.4 protein serine/threonine kinase activity
38 GO0016740 395 +3.943 139.2 transferase activity
39 GO0008610 80 +3.930 163.4 lipid biosynthesis
40 GO0000082 30 +3.866 185.7 G1/S transition of mitotic cell cycle
41 GO0019740 10 +3.827 230.3 nitrogen utilization
42 GO0005933 84 +3.805 160.0 bud
43 GO0006807 23 +3.687 189.1 nitrogen metabolism
44 GO0004693 20 +3.615 192.2 cyclin-dependent protein kinase activity
45 GO0004672 95 +3.605 156.2 protein kinase activity
46 GO0030528 188 +3.533 144.8 transcription regulator activity
47 GO0006796 97 +3.530 152.4 phosphate metabolism
48 GO0006793 97 +3.530 152.4 phosphorus metabolism
49 GO0005934 34 +3.372 174.1 bud tip
50 GO0005215 206 +3.362 142.4 transporter activity
51 GO0006869 10 +3.331 216.5 lipid transport
52 GO0005386 58 +3.323 161.0 carrier activity
53 GO0019887 17 +3.248 189.5 protein kinase regulator activity
54 GO0008361 7 +3.223 229.0 regulation of cell size
55 GO0005489 14 +3.202 200.1 electron transporter activity
56 GO0004553 15 +3.125 191.1 hydrolase activity, hydrolyzing O-glycosyl compounds
57 GO0045229 78 +3.098 154.4 external encapsulating structure organization and biogenesis
58 GO0007047 78 +3.098 154.4 cell wall organization and biogenesis
59 GO0000086 19 +3.084 183.4 G2/M transition of mitotic cell cycle
60 GO0030483 86 +2.985 151.2 site of polarized growth (sensu Fungi)
61 GO0030427 86 +2.985 151.2 site of polarized growth
62 GO0000134 86 +2.985 151.2 site of polarized growth (sensu Saccharomyces)
63 GO0016051 39 +2.982 163.7 carbohydrate biosynthesis
64 GO0006355 169 +2.967 141.6 regulation of transcription, DNA-dependent
65 GO0019752 126 +2.960 145.1 carboxylic acid metabolism
66 GO0006082 126 +2.960 145.1 organic acid metabolism
67 GO0007275 205 +2.934 140.8 development
68 GO0007124 29 +2.926 168.9 pseudohyphal growth
69 GO0005976 25 +2.916 173.5 polysaccharide metabolism
70 GO0006357 100 +2.905 147.7 regulation of transcription from Pol II promoter
71 GO0005886 100 +2.905 147.4 plasma membrane
72 GO0045449 175 +2.892 142.0 regulation of transcription
73 GO0009058 477 +2.846 133.9 biosynthesis
74 GO0000079 9 +2.838 208.6 regulation of CDK activity
75 GO0006118 11 +2.818 199.1 electron transport
76 GO0006633 7 +2.807 215.3 fatty acid biosynthesis
77 GO0006094 20 +2.806 176.9 gluconeogenesis
78 GO0003824 1075 +2.798 129.1 catalytic activity
79 GO0046483 42 +2.788 159.1 heterocycle metabolism
80 GO0042626 23 +2.780 173.0 ATPase activity, coupled to transmembrane movement of substances
81 GO0016820 23 +2.780 173.0 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
82 GO0015405 23 +2.780 173.0 P-P-bond-hydrolysis-driven transporter activity
83 GO0040020 11 +2.747 197.0 regulation of meiosis
84 GO0003704 28 +2.746 169.4 specific RNA polymerase II transcription factor activity
85 GO0005199 6 +2.732 224.7 structural constituent of cell wall
86 GO0015846 6 +2.705 223.3 polyamine transport
87 GO0016798 20 +2.704 174.3 hydrolase activity, acting on glycosyl bonds
88 GO0006164 28 +2.688 168.4 purine nucleotide biosynthesis
89 GO0015399 31 +2.679 164.2 primary active transporter activity
90 GO0016903 8 +2.673 206.6 oxidoreductase activity, acting on the aldehyde or oxo group of donors
91 GO0016310 76 +2.657 149.1 phosphorylation
92 GO0006113 6 +2.651 221.8 fermentation
93 GO0015926 9 +2.642 202.6 glucosidase activity
94 GO0007154 110 +2.630 144.8 cell communication
95 GO0016879 31 +2.617 163.7 ligase activity, forming carbon-nitrogen bonds
96 GO0009165 31 +2.617 163.5 nucleotide biosynthesis
97 GO0006163 30 +2.609 164.2 purine nucleotide metabolism
98 GO0048066 9 +2.609 201.2 pigmentation
99 GO0046148 9 +2.609 201.2 pigment biosynthesis
100 GO0042440 9 +2.609 201.2 pigment metabolism
101 GO0042168 9 +2.609 201.2 heme metabolism
102 GO0006783 9 +2.609 201.2 heme biosynthesis
103 GO0006779 9 +2.609 201.2 porphyrin biosynthesis
104 GO0006778 9 +2.609 201.2 porphyrin metabolism
105 GO0003700 27 +2.596 167.6 transcription factor activity
106 GO0001403 17 +2.577 175.1 invasive growth (sensu Saccharomyces)
107 GO0007096 6 +2.570 218.2 regulation of exit from mitosis
108 GO0006631 23 +2.567 168.2 fatty acid metabolism
109 GO0016769 8 +2.547 202.2 transferase activity, transferring nitrogenous groups
110 GO0008483 8 +2.547 202.2 transaminase activity
111 GO0046165 22 +2.516 170.2 alcohol biosynthesis
112 GO0015075 61 +2.503 151.1 ion transporter activity
113 GO0006073 18 +2.494 172.5 glucan metabolism
114 GO0030120 20 +2.401 168.6 vesicle coat
115 GO0046364 21 +2.368 168.6 monosaccharide biosynthesis
116 GO0019319 21 +2.368 168.6 hexose biosynthesis
117 GO0030004 14 +2.350 179.6 monovalent inorganic cation homeostasis
118 GO0006112 16 +2.339 175.2 energy reserve metabolism
119 GO0006468 58 +2.302 148.3 protein amino acid phosphorylation
120 GO0000271 13 +2.300 179.8 polysaccharide biosynthesis
121 GO0000122 23 +2.300 163.7 negative regulation of transcription from Pol II promoter
122 GO0006665 18 +2.255 167.6 sphingolipid metabolism
123 GO0007165 100 +2.233 141.6 signal transduction
124 GO0042775 7 +2.211 195.4 ATP synthesis coupled electron transport (sensu Eukarya)
125 GO0042773 7 +2.211 195.4 ATP synthesis coupled electron transport
126 GO0006129 7 +2.211 195.4 protein-disulfide reduction
127 GO0003714 8 +2.202 191.8 transcription co-repressor activity
128 GO0009117 37 +2.189 152.9 nucleotide metabolism
129 GO0008135 32 +2.175 154.1 translation factor activity, nucleic acid binding
130 GO0046394 11 +2.173 181.6 carboxylic acid biosynthesis
131 GO0016053 11 +2.173 181.6 organic acid biosynthesis
132 GO0008324 49 +2.159 149.5 cation transporter activity
133 GO0007242 60 +2.143 147.0 intracellular signaling cascade
134 GO0006414 11 +2.137 180.6 translational elongation
135 GO0008652 57 +2.133 146.7 amino acid biosynthesis
136 GO0019207 24 +2.121 163.1 kinase regulator activity
137 GO0030641 10 +2.094 181.6 hydrogen ion homeostasis
138 GO0006885 10 +2.094 181.6 regulation of pH
139 GO0019222 21 +2.068 162.3 regulation of metabolism
140 GO0009435 6 +2.059 199.2 nicotinamide adenine dinucleotide biosynthesis
141 GO0009309 60 +2.057 145.4 amine biosynthesis
142 GO0009894 7 +2.033 189.6 regulation of catabolism
143 GO0007264 36 +2.029 150.6 small GTPase mediated signal transduction
144 GO0030148 13 +2.026 172.9 sphingolipid biosynthesis
145 GO0045182 38 +2.024 151.6 translation regulator activity
146 GO0015203 9 +2.019 183.7 polyamine transporter activity
147 GO0007088 18 +2.015 162.6 regulation of mitosis
148 GO0000131 18 +2.015 162.5 incipient bud site
149 GO0016638 6 +2.005 197.3 oxidoreductase activity, acting on the CH-NH2 group of donors
150 GO0003746 10 +1.987 178.9 translation elongation factor activity
151 GO0006090 6 +1.978 196.5 pyruvate metabolism
152 GO0006087 6 +1.978 196.5 pyruvate dehydrogenase bypass
153 GO0004871 40 +1.954 149.5 signal transducer activity
154 GO0006099 9 +1.953 181.4 tricarboxylic acid cycle
155 GO0000307 6 +1.951 195.0 cyclin-dependent protein kinase holoenzyme complex
156 GO0016616 30 +1.951 153.2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
157 GO0005941 20 +1.946 159.9 unlocalized
158 GO0005935 62 +1.940 143.7 bud neck
159 GO0006513 12 +1.936 171.5 protein monoubiquitination
160 GO0004009 12 +1.936 171.3 ATP-binding cassette (ABC) transporter activity
161 GO0030117 23 +1.927 156.9 membrane coat
162 GO0042625 11 +1.923 174.7 ATPase activity, coupled to transmembrane movement of ions
163 GO0000209 11 +1.923 174.4 protein polyubiquitination
164 GO0006100 9 +1.920 180.9 TCA intermediate metabolism
165 GO0007015 37 +1.913 148.6 actin filament organization
166 GO0003702 78 +1.866 141.6 RNA polymerase II transcription factor activity
167 GO0009112 20 +1.845 157.0 nucleobase metabolism
168 GO0004872 12 +1.821 168.7 receptor activity
169 GO0016481 64 +1.815 142.3 negative regulation of transcription
170 GO0005937 24 +1.814 157.7 shmoo tip
171 GO0006413 25 +1.804 153.4 translational initiation
172 GO0016651 8 +1.795 178.2 oxidoreductase activity, acting on NADH or NADPH
173 GO0016614 37 +1.775 147.0 oxidoreductase activity, acting on CH-OH group of donors
174 GO0019674 8 +1.763 177.5 nicotinamide adenine dinucleotide metabolism
175 GO0006520 81 +1.763 139.0 amino acid metabolism
176 GO0006519 88 +1.745 137.4 amino acid and derivative metabolism
177 GO0006873 48 +1.738 143.9 cell ion homeostasis
178 GO0016020 468 +1.719 128.3 membrane
179 GO0005746 12 +1.706 165.6 mitochondrial electron transport chain
180 GO0008134 20 +1.693 154.9 transcription factor binding
181 GO0006811 50 +1.691 145.0 ion transport
182 GO0006144 10 +1.669 169.5 purine base metabolism
183 GO0045941 33 +1.656 146.4 positive regulation of transcription
184 GO0042598 7 +1.646 176.1 vesicular fraction
185 GO0005792 7 +1.646 176.1 microsome
186 GO0003743 19 +1.645 154.5 translation initiation factor activity
187 GO0009991 6 +1.627 183.5 response to extracellular stimulus
188 GO0005319 9 +1.593 170.2 lipid transporter activity
189 GO0007568 20 +1.592 152.7 aging
190 GO0008509 12 +1.592 162.7 anion transporter activity
191 GO0005977 12 +1.592 162.2 glycogen metabolism
192 GO0015291 15 +1.577 156.4 porter activity
193 GO0015290 15 +1.577 156.4 electrochemical potential-driven transporter activity
194 GO0030003 41 +1.570 143.8 cation homeostasis
195 GO0019363 7 +1.556 173.0 pyridine nucleotide biosynthesis
196 GO0006820 13 +1.556 160.2 anion transport
197 GO0015078 23 +1.553 149.1 hydrogen ion transporter activity
198 GO0046112 12 +1.553 161.3 nucleobase biosynthesis
199 GO0030036 50 +1.541 142.3 actin cytoskeleton organization and biogenesis
200 GO0015077 25 +1.526 148.2 monovalent inorganic cation transporter activity
201 GO0030234 101 +1.513 134.4 enzyme regulator activity
202 GO0016620 6 +1.493 178.3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
203 GO0045892 63 +1.490 139.9 negative regulation of transcription, DNA-dependent
204 GO0006119 18 +1.488 151.5 oxidative phosphorylation
205 GO0006366 157 +1.461 132.4 transcription from Pol II promoter
206 GO0016567 14 +1.456 157.6 protein ubiquitination
207 GO0004722 21 +1.418 149.2 protein serine/threonine phosphatase activity
208 GO0016765 24 +1.403 149.0 transferase activity, transferring alkyl or aryl (other than methyl) groups
209 GO0042592 54 +1.394 138.7 homeostasis
210 GO0019725 54 +1.394 138.7 cell homeostasis
211 GO0030029 52 +1.385 138.8 actin filament-based process
212 GO0009308 98 +1.373 134.6 amine metabolism
213 GO0016874 58 +1.367 137.0 ligase activity
214 GO0016763 12 +1.362 156.2 transferase activity, transferring pentosyl groups
215 GO0015711 6 +1.358 173.7 organic anion transport
216 GO0007035 6 +1.358 173.8 vacuolar acidification
217 GO0003697 6 +1.358 173.0 single-stranded DNA binding
218 GO0045893 30 +1.352 144.0 positive regulation of transcription, DNA-dependent
219 GO0005829 173 +1.344 130.7 cytosol
220 GO0019856 8 +1.324 163.8 pyrimidine base biosynthesis
221 GO0016265 21 +1.318 147.8 death
222 GO0000074 64 +1.298 136.1 regulation of cell cycle
223 GO0003712 18 +1.296 147.2 transcription cofactor activity
224 GO0019362 22 +1.290 146.6 pyridine nucleotide metabolism
225 GO0006769 22 +1.290 146.6 nicotinamide metabolism
226 GO0005548 7 +1.289 164.0 phospholipid transporter activity
227 GO0030137 13 +1.281 153.5 COPI-coated vesicle
228 GO0016582 57 +1.278 136.7 non-covalent chromatin modification
229 GO0006338 57 +1.278 136.7 chromatin modeling
230 GO0007569 19 +1.248 146.5 cell aging
231 GO0009084 13 +1.242 152.6 glutamine family amino acid biosynthesis
232 GO0000790 22 +1.239 145.9 nuclear chromatin
233 GO0046219 8 +1.230 160.5 indolalkylamine biosynthesis
234 GO0042435 8 +1.230 160.5 indole derivative biosynthesis
235 GO0042434 8 +1.230 160.5 indole derivative metabolism
236 GO0042430 8 +1.230 160.5 indole and derivative metabolism
237 GO0009096 8 +1.230 160.5 aromatic amino acid family biosynthesis, anthranilate pathway
238 GO0006586 8 +1.230 160.5 indolalkylamine metabolism
239 GO0006568 8 +1.230 160.5 tryptophan metabolism
240 GO0000162 8 +1.230 160.5 tryptophan biosynthesis
241 GO0005811 21 +1.218 145.6 lipid particle
242 GO0006725 35 +1.213 139.5 aromatic compound metabolism
243 GO0009082 10 +1.209 156.1 branched chain family amino acid biosynthesis
244 GO0009250 9 +1.167 157.2 glucan biosynthesis
245 GO0019932 13 +1.164 150.6 second-messenger-mediated signaling
246 GO0016563 24 +1.147 144.8 transcriptional activator activity
247 GO0005789 63 +1.146 135.6 endoplasmic reticulum membrane
248 GO0005100 6 +1.143 165.5 Rho GTPase activator activity
249 GO0030468 52 +1.142 135.6 establishment of cell polarity (sensu Fungi)
250 GO0030010 52 +1.142 135.6 establishment of cell polarity
251 GO0000283 52 +1.142 135.6 establishment of cell polarity (sensu Saccharomyces)
252 GO0009081 11 +1.134 152.6 branched chain family amino acid metabolism
253 GO0006512 26 +1.127 141.4 ubiquitin cycle
254 GO0016311 16 +1.121 147.9 dephosphorylation
255 GO0007117 16 +1.077 146.0 bud growth
256 GO0000785 23 +1.073 140.8 chromatin
257 GO0004659 10 +1.068 152.6 prenyltransferase activity
258 GO0005083 33 +1.066 137.2 small GTPase regulatory/interacting protein activity
259 GO0042401 11 +1.063 150.1 biogenic amine biosynthesis
260 GO0004428 6 +1.062 162.7 inositol/phosphatidylinositol kinase activity
261 GO0042398 12 +1.055 148.0 amino acid derivative biosynthesis
262 GO0009266 8 +1.042 154.6 response to temperature
263 GO0005576 9 +1.035 153.4 extracellular
264 GO0008219 20 +1.035 141.7 cell death
265 GO0006914 22 +1.035 141.6 autophagy
266 GO0004842 16 +1.034 145.6 ubiquitin-protein ligase activity
267 GO0004721 32 +1.026 136.7 protein phosphatase activity
268 GO0045944 25 +1.025 139.8 positive regulation of transcription from Pol II promoter
269 GO0019438 13 +1.007 146.4 aromatic compound biosynthesis
270 GO0009073 13 +1.007 146.4 aromatic amino acid family biosynthesis
271 GO0042175 72 +1.007 132.4 nuclear envelope-endoplasmic reticulum network
272 GO0046138 43 +1.006 134.8 coenzymes and prosthetic group biosynthesis
273 GO0042623 55 +1.005 133.8 ATPase activity, coupled
274 GO0006790 30 +0.993 137.9 sulfur metabolism
275 GO0006731 75 +0.993 132.4 coenzymes and prosthetic group metabolism
276 GO0016585 11 +0.991 148.4 chromatin remodeling complex
277 GO0030880 20 +0.985 140.5 RNA polymerase complex
278 GO0019935 8 +0.979 152.1 cyclic-nucleotide-mediated signaling
279 GO0019933 8 +0.979 152.1 cAMP-mediated signaling
280 GO0007093 9 +0.970 151.7 mitotic checkpoint
281 GO0019751 6 +0.954 158.8 polyol metabolism
282 GO0006071 6 +0.954 158.8 glycerol metabolism
283 GO0008320 8 +0.948 151.8 protein carrier activity
284 GO0009260 17 +0.946 141.0 ribonucleotide biosynthesis
285 GO0009152 17 +0.946 141.0 purine ribonucleotide biosynthesis
286 GO0009064 17 +0.946 141.8 glutamine family amino acid metabolism
287 GO0030467 53 +0.946 134.5 establishment and/or maintenance of cell polarity (sensu Fungi)
288 GO0030012 53 +0.946 134.5 establishment and/or maintenance of cell polarity (sensu Saccharomyces)
289 GO0007163 53 +0.946 134.5 establishment and/or maintenance of cell polarity
290 GO0006890 11 +0.919 146.2 retrograde (Golgi to ER) transport
291 GO0003899 21 +0.918 139.1 DNA-directed RNA polymerase activity
292 GO0006575 15 +0.913 141.0 amino acid derivative metabolism
293 GO0006734 6 +0.900 156.7 NADH metabolism
294 GO0006555 14 +0.888 143.9 methionine metabolism
295 GO0006470 14 +0.888 143.9 protein amino acid dephosphorylation
296 GO0006445 14 +0.888 143.7 regulation of translation
297 GO0046486 8 +0.885 149.0 glycerolipid metabolism
298 GO0006662 8 +0.885 149.0 glycerol ether metabolism
299 GO0006641 8 +0.885 149.0 triacylglycerol metabolism
300 GO0006639 8 +0.885 149.0 acylglycerol metabolism
301 GO0006638 8 +0.885 149.0 neutral lipid metabolism
302 GO0005679 8 +0.885 149.2 nucleosome remodeling complex
303 GO0009060 35 +0.879 134.7 aerobic respiration
304 GO0007265 12 +0.864 143.8 RAS protein signal transduction
305 GO0045047 16 +0.859 141.9 protein-ER targeting
306 GO0007266 10 +0.856 146.8 Rho protein signal transduction
307 GO0000137 8 +0.854 148.9 Golgi cis cisterna
308 GO0006576 14 +0.847 142.1 biogenic amine metabolism
309 GO0015662 6 +0.846 154.5 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
310 GO0008535 6 +0.846 154.5 cytochrome c oxidase biogenesis
311 GO0006462 6 +0.846 154.5 protein complex assembly, multichaperone pathway
312 GO0016568 92 +0.841 129.3 chromatin modification
313 GO0040029 39 +0.839 133.9 regulation of gene expression, epigenetic
314 GO0006812 36 +0.835 133.6 cation transport
315 GO0016881 22 +0.831 137.4 acid-D-amino acid ligase activity
316 GO0009072 15 +0.825 139.3 aromatic amino acid family metabolism
317 GO0008514 8 +0.823 147.2 organic anion transporter activity
318 GO0008028 8 +0.823 147.2 monocarboxylic acid transporter activity
319 GO0006206 10 +0.785 144.5 pyrimidine base metabolism
320 GO0005774 49 +0.782 131.3 vacuolar membrane
321 GO0005758 15 +0.781 138.7 mitochondrial intermembrane space
322 GO0007231 9 +0.773 145.1 osmosensory signaling pathway
323 GO0005940 9 +0.773 145.7 septin ring
324 GO0003677 107 +0.766 127.7 DNA binding
325 GO0030127 6 +0.765 151.0 COPII vesicle coat
326 GO0016627 8 +0.760 145.9 oxidoreductase activity, acting on the CH-CH group of donors
327 GO0007029 17 +0.755 137.4 ER organization and biogenesis
328 GO0006733 30 +0.754 133.2 oxidoreduction coenzyme metabolism
329 GO0005275 23 +0.753 134.2 amine/polyamine transporter activity
330 GO0006791 7 +0.753 146.7 sulfur utilization
331 GO0000103 7 +0.753 146.7 sulfate assimilation
332 GO0000075 19 +0.751 136.7 cell cycle checkpoint
333 GO0000183 10 +0.749 143.7 chromatin silencing at ribosomal DNA (rDNA)
334 GO0019866 84 +0.737 128.2 inner membrane
335 GO0005743 84 +0.737 128.2 mitochondrial inner membrane
336 GO0015992 13 +0.733 139.3 proton transport
337 GO0015672 13 +0.733 139.3 monovalent inorganic cation transport
338 GO0006818 13 +0.733 139.3 hydrogen transport
339 GO0006348 20 +0.732 135.4 chromatin silencing at telomere
340 GO0019205 6 +0.711 149.3 nucleobase, nucleoside, nucleotide kinase activity
341 GO0005887 12 +0.711 139.0 integral to plasma membrane
342 GO0004407 12 +0.711 139.9 histone deacetylase activity
343 GO0009076 9 +0.708 143.7 histidine family amino acid biosynthesis
344 GO0009075 9 +0.708 143.7 histidine family amino acid metabolism
345 GO0006547 9 +0.708 143.7 histidine metabolism
346 GO0000105 9 +0.708 143.7 histidine biosynthesis
347 GO0005783 217 +0.702 125.4 endoplasmic reticulum
348 GO0007582 2387 +0.701 123.4 physiological processes
349 GO0009066 23 +0.700 133.7 aspartate family amino acid metabolism
350 GO0030125 8 +0.697 143.2 clathrin vesicle coat
351 GO0030118 8 +0.697 143.2 clathrin coat
352 GO0045333 36 +0.695 131.0 cellular respiration
353 GO0042546 6 +0.685 148.8 cell wall biosynthesis
354 GO0009272 6 +0.685 148.8 cell wall biosynthesis (sensu Fungi)
355 GO0007120 10 +0.679 141.5 axial budding
356 GO0006970 34 +0.676 131.4 response to osmotic stress
357 GO0009259 18 +0.673 134.7 ribonucleotide metabolism
358 GO0009150 18 +0.673 134.7 purine ribonucleotide metabolism
359 GO0000151 17 +0.659 135.2 ubiquitin ligase complex
360 GO0009127 6 +0.658 147.0 purine nucleoside monophosphate biosynthesis
361 GO0009124 6 +0.658 147.0 nucleoside monophosphate biosynthesis
362 GO0006875 28 +0.654 133.1 metal ion homeostasis
363 GO0019867 15 +0.648 135.2 outer membrane
364 GO0005741 15 +0.648 135.2 mitochondrial outer membrane
365 GO0006950 209 +0.647 125.2 response to stress
366 GO0006350 372 +0.646 124.4 transcription
367 GO0009067 10 +0.643 140.9 aspartate family amino acid biosynthesis
368 GO0006613 10 +0.643 140.8 cotranslational membrane targeting
369 GO0016747 43 +0.640 129.2 transferase activity, transferring groups other than amino-acyl groups
370 GO0001301 6 +0.631 146.2 progressive alteration of chromatin during cell aging
371 GO0015698 9 +0.609 140.0 inorganic anion transport
372 GO0046527 7 +0.604 141.9 glucosyltransferase activity
373 GO0009415 8 +0.603 140.2 response to water
374 GO0009414 8 +0.603 140.2 response to water deprivation
375 GO0009269 8 +0.603 140.2 response to dessication
376 GO0000096 19 +0.602 133.6 sulfur amino acid metabolism
377 GO0006325 102 +0.596 126.8 establishment and/or maintenance of chromatin architecture
378 GO0006323 102 +0.596 126.8 DNA packaging
379 GO0007243 12 +0.596 136.2 protein kinase cascade
380 GO0003925 20 +0.580 132.8 small monomeric GTPase activity
381 GO0016830 13 +0.576 135.5 carbon-carbon lyase activity
382 GO0009892 7 +0.574 140.0 negative regulation of metabolism
383 GO0005740 105 +0.572 126.7 mitochondrial membrane
384 GO0007166 21 +0.567 132.1 cell surface receptor linked signal transduction
385 GO0019898 15 +0.560 133.5 extrinsic to membrane
386 GO0016836 16 +0.555 134.8 hydro-lyase activity
387 GO0006767 36 +0.554 129.5 water-soluble vitamin metabolism
388 GO0006766 36 +0.554 129.5 vitamin metabolism
389 GO0005773 100 +0.554 126.2 vacuole
390 GO0016575 8 +0.540 138.5 histone deacetylation
391 GO0006353 8 +0.540 138.4 transcription termination
392 GO0006303 10 +0.537 137.1 double-strand break repair via nonhomologous end-joining
393 GO0008565 25 +0.525 130.2 protein transporter activity
394 GO0015837 26 +0.524 131.0 amine/polyamine transport
395 GO0009206 12 +0.519 134.8 purine ribonucleoside triphosphate biosynthesis
396 GO0009205 12 +0.519 134.8 purine ribonucleoside triphosphate metabolism
397 GO0009201 12 +0.519 134.8 ribonucleoside triphosphate biosynthesis
398 GO0009199 12 +0.519 134.8 ribonucleoside triphosphate metabolism
399 GO0009145 12 +0.519 134.8 purine nucleoside triphosphate biosynthesis
400 GO0009144 12 +0.519 134.8 purine nucleoside triphosphate metabolism
401 GO0009142 12 +0.519 134.8 nucleoside triphosphate biosynthesis
402 GO0000910 40 +0.509 128.1 cytokinesis
403 GO0004536 11 +0.489 134.8 deoxyribonuclease activity
404 GO0006616 7 +0.485 137.7 SRP-dependent cotranslational membrane targeting, translocation
405 GO0007001 114 +0.475 125.2 chromosome organization and biogenesis (sensu Eukarya)
406 GO0030466 13 +0.458 132.2 chromatin silencing at silent mating-type cassettes (sensu Fungi)
407 GO0006347 13 +0.458 132.2 chromatin silencing at HML and HMR (sensu Saccharomyces)
408 GO0045263 8 +0.446 135.1 proton-transporting ATP synthase complex, coupling factor F(o)
409 GO0000276 8 +0.446 135.1 proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukarya)
410 GO0004840 9 +0.446 135.6 ubiquitin conjugating enzyme activity
411 GO0030473 6 +0.442 139.7 nuclear migration (sensu Fungi)
412 GO0000065 6 +0.442 139.7 nuclear migration (sensu Saccharomyces)
413 GO0000165 10 +0.431 134.4 MAPKKK cascade
414 GO0016757 60 +0.428 126.7 transferase activity, transferring glycosyl groups
415 GO0007234 7 +0.425 135.0 osmosensory signaling pathway via two-component system
416 GO0000160 7 +0.425 135.0 two-component signal transduction system (phosphorelay)
417 GO0046873 17 +0.419 130.3 metal ion transporter activity
418 GO0045277 6 +0.415 138.2 respiratory chain complex IV
419 GO0016676 6 +0.415 138.2 oxidoreductase activity, acting on heme group of donors, oxygen as acceptor
420 GO0016675 6 +0.415 138.2 oxidoreductase activity, acting on heme group of donors
421 GO0015002 6 +0.415 138.2 heme-copper terminal oxidase activity
422 GO0005751 6 +0.415 138.2 respiratory chain complex IV (sensu Eukarya)
423 GO0004129 6 +0.415 138.2 cytochrome-c oxidase activity
424 GO0006997 141 +0.410 124.2 nuclear organization and biogenesis
425 GO0016023 56 +0.397 126.5 cytoplasmic vesicle
426 GO0030864 37 +0.395 126.2 cortical actin cytoskeleton
427 GO0030863 37 +0.395 126.2 cortical cytoskeleton
428 GO0009607 30 +0.395 127.6 response to biotic stimulus
429 GO0009141 13 +0.380 130.8 nucleoside triphosphate metabolism
430 GO0006109 13 +0.380 130.8 regulation of carbohydrate metabolism
431 GO0030479 21 +0.367 128.6 actin cortical patch (sensu Fungi)
432 GO0005857 21 +0.367 128.6 actin cortical patch (sensu Saccharomyces)
433 GO0003924 34 +0.363 126.4 GTPase activity
434 GO0008374 6 +0.361 136.2 O-acyltransferase activity
435 GO0008639 10 +0.360 132.7 small protein conjugating enzyme activity
436 GO0005795 10 +0.360 132.3 Golgi stack
437 GO0009987 1339 +0.352 122.4 cellular process
438 GO0008152 1726 +0.352 122.1 metabolism
439 GO0008151 1286 +0.352 122.4 cell growth and/or maintenance
440 GO0019954 47 +0.345 126.8 asexual reproduction
441 GO0007114 47 +0.345 126.8 budding
442 GO0042578 55 +0.341 126.0 phosphoric ester hydrolase activity
443 GO0006057 7 +0.336 132.1 mannoprotein biosynthesis
444 GO0006056 7 +0.336 132.1 mannoprotein metabolism
445 GO0000032 7 +0.336 132.1 cell wall mannoprotein biosynthesis
446 GO0016746 52 +0.330 125.2 transferase activity, transferring acyl groups
447 GO0016485 12 +0.328 129.0 protein processing
448 GO0045814 37 +0.326 125.3 negative regulation of gene expression, epigenetic
449 GO0006342 37 +0.326 125.3 chromatin silencing
450 GO0003773 10 +0.325 131.6 heat shock protein activity
451 GO0015082 17 +0.323 128.5 di-, tri-valent inorganic cation transporter activity
452 GO0009167 6 +0.307 134.3 purine ribonucleoside monophosphate metabolism
453 GO0009161 6 +0.307 134.3 ribonucleoside monophosphate metabolism
454 GO0005938 62 +0.305 124.8 cell cortex
455 GO0016021 112 +0.302 124.5 integral to membrane
456 GO0016791 51 +0.297 125.5 phosphoric monoester hydrolase activity
457 GO0046916 20 +0.276 126.7 transition metal ion homeostasis
458 GO0042364 17 +0.275 127.2 water-soluble vitamin biosynthesis
459 GO0009110 17 +0.275 127.2 vitamin biosynthesis
460 GO0005096 24 +0.275 127.9 GTPase activator activity
461 GO0000288 13 +0.262 127.5 mRNA catabolism, deadenylation-dependent
462 GO0009126 7 +0.247 129.9 purine nucleoside monophosphate metabolism
463 GO0009123 7 +0.247 129.9 nucleoside monophosphate metabolism
464 GO0005342 27 +0.234 125.0 organic acid transporter activity
465 GO0030695 40 +0.233 124.0 GTPase regulator activity
466 GO0006614 8 +0.227 128.9 SRP-dependent cotranslational membrane targeting
467 GO0016835 20 +0.226 125.0 carbon-oxygen lyase activity
468 GO0006351 349 +0.225 122.8 transcription, DNA-dependent
469 GO0030005 24 +0.224 126.2 di-, tri-valent inorganic cation homeostasis
470 GO0030363 10 +0.219 128.6 pre-mRNA cleavage factor activity
471 GO0009069 10 +0.219 128.9 serine family amino acid metabolism
472 GO0007155 7 +0.217 128.0 cell adhesion
473 GO0000278 188 +0.215 122.4 mitotic cell cycle
474 GO0000118 16 +0.207 126.8 histone deacetylase complex
475 GO0006476 11 +0.203 126.3 protein amino acid deacetylation
476 GO0016780 6 +0.200 130.0 phosphotransferase activity, for other substituted phosphate groups
477 GO0046943 25 +0.191 124.9 carboxylic acid transporter activity
478 GO0030150 13 +0.184 125.2 mitochondrial matrix protein import
479 GO0042273 10 +0.184 127.3 ribosomal large subunit biogenesis
480 GO0003928 6 +0.173 129.3 RAB small monomeric GTPase activity
481 GO0006643 60 +0.171 123.4 membrane lipid metabolism
482 GO0007094 8 +0.164 126.8 mitotic spindle checkpoint
483 GO0006732 66 +0.162 123.1 coenzyme metabolism
484 GO0019897 7 +0.157 126.4 extrinsic to plasma membrane
485 GO0016829 44 +0.157 123.6 lyase activity
486 GO0008047 44 +0.157 123.8 enzyme activator activity
487 GO0006493 9 +0.151 126.9 O-linked glycosylation
488 GO0006369 7 +0.128 125.0 transcription termination from Pol II promoter
489 GO0030135 47 +0.125 123.6 coated vesicle
490 GO0030015 6 +0.119 127.2 CCR4-NOT core complex
491 GO0000289 6 +0.119 127.2 poly(A) tail shortening
492 GO0009889 10 +0.113 125.4 regulation of biosynthesis
493 GO0007105 10 +0.113 125.8 cytokinesis, site selection
494 GO0000282 10 +0.113 125.8 bud site selection
495 GO0030138 13 +0.106 123.3 COPII-coated vesicle
496 GO0006879 13 +0.106 123.5 iron ion homeostasis
497 GO0008415 42 +0.104 122.6 acyltransferase activity
498 GO0007531 8 +0.101 124.5 mating-type determination
499 GO0007530 8 +0.101 124.5 sex determination
500 GO0007097 8 +0.101 124.9 nuclear migration
501 GO0046034 11 +0.095 123.5 ATP metabolism
502 GO0045259 11 +0.095 123.5 proton-transporting ATP synthase complex
503 GO0045255 11 +0.095 123.5 hydrogen-translocating F-type ATPase complex
504 GO0016469 11 +0.095 123.5 proton-transporting two-sector ATPase complex
505 GO0015986 11 +0.095 123.5 ATP synthesis coupled proton transport
506 GO0015985 11 +0.095 123.5 energy coupled proton transport, down the electrochemical gradient
507 GO0006754 11 +0.095 123.5 ATP biosynthesis
508 GO0006753 11 +0.095 123.5 nucleoside phosphate metabolism
509 GO0005753 11 +0.095 123.5 proton-transporting ATP synthase complex (sensu Eukarya)
510 GO0016282 25 +0.080 122.5 eukaryotic 43S preinitiation complex
511 GO0030478 16 +0.076 123.0 actin cap (sensu Fungi)
512 GO0000143 16 +0.076 123.0 actin cap (sensu Saccharomyces)
513 GO0045896 8 +0.070 123.4 regulation of transcription, mitotic
514 GO0007068 8 +0.070 123.4 negative regulation of transcription, mitotic
515 GO0005849 6 +0.065 125.8 mRNA cleavage factor complex
516 GO0006612 12 +0.060 122.1 protein-membrane targeting
517 GO0005625 18 +0.049 121.6 soluble fraction
518 GO0006111 7 +0.038 122.4 regulation of gluconeogenesis
519 GO0045912 6 +0.038 124.5 negative regulation of carbohydrate metabolism
520 GO0045721 6 +0.038 124.5 negative regulation of gluconeogenesis
521 GO0009890 6 +0.038 124.5 negative regulation of biosynthesis
522 GO0009056 182 +0.021 121.8 catabolism
523 GO0046942 24 +0.018 122.8 carboxylic acid transport
524 GO0015849 24 +0.018 122.8 organic acid transport
525 GO0009605 133 +0.010 121.1 response to external stimulus
526 GO0005737 1896 +0.003 121.4 cytoplasm
527 GO0005623 2869 +0.003 121.5 cell
528 GO0003674 3253 +0.003 121.0 molecular_function
529 GO0019213 14 -0.006 121.0 deacetylase activity
530 GO0046933 9 -0.013 121.2 hydrogen-transporting ATP synthase activity, rotational mechanism
531 GO0016779 48 -0.014 121.1 nucleotidyltransferase activity
532 GO0006378 15 -0.015 120.1 mRNA polyadenylation
533 GO0006388 6 -0.016 122.5 tRNA splicing
534 GO0000394 6 -0.016 122.5 RNA splicing, via endonucleolytic cleavage and ligation
535 GO0000139 12 -0.017 120.9 Golgi membrane
536 GO0030866 8 -0.024 120.5 cortical actin cytoskeleton organization and biogenesis
537 GO0030865 8 -0.024 120.5 cortical cytoskeleton organization and biogenesis
538 GO0000147 8 -0.024 120.5 actin cortical patch assembly
539 GO0000030 26 -0.024 120.6 mannosyltransferase activity
540 GO0006800 25 -0.031 120.4 oxygen and reactive oxygen species metabolism
541 GO0016458 41 -0.040 121.4 gene silencing
542 GO0016440 41 -0.040 121.4 transcriptional gene silencing
543 GO0006740 6 -0.043 121.8 NADPH regeneration
544 GO0000726 19 -0.043 120.2 non-recombinational repair
545 GO0016579 12 -0.055 119.4 protein deubiquitination
546 GO0005736 12 -0.055 119.8 DNA-directed RNA polymerase I complex
547 GO0001302 12 -0.055 119.5 replicative cell aging
548 GO0008643 7 -0.081 118.4 carbohydrate transport
549 GO0006379 11 -0.084 118.5 mRNA cleavage
550 GO0018193 7 -0.110 117.4 peptidyl-amino acid modification
551 GO0009628 105 -0.118 120.8 response to abiotic stimulus
552 GO0006464 243 -0.136 120.3 protein modification
553 GO0000324 75 -0.142 120.5 vacuole (sensu Fungi)
554 GO0000323 75 -0.142 120.5 lytic vacuole
555 GO0000322 75 -0.142 120.5 storage vacuole
556 GO0030119 8 -0.149 116.9 membrane coat adaptor complex
557 GO0007118 8 -0.149 116.6 apical bud growth
558 GO0030014 11 -0.156 116.8 CCR4-NOT complex
559 GO0007186 13 -0.169 116.0 G-protein coupled receptor protein signaling pathway
560 GO0016758 48 -0.173 119.4 transferase activity, transferring hexosyl groups
561 GO0030364 9 -0.177 116.9 cleavage/polyadenylation specificity factor activity
562 GO0006525 9 -0.177 116.7 arginine metabolism
563 GO0000051 9 -0.177 116.7 urea cycle intermediate metabolism
564 GO0015674 20 -0.179 117.0 di-, tri-valent inorganic cation transport
565 GO0046467 46 -0.181 119.8 membrane lipid biosynthesis
566 GO0008289 11 -0.191 115.2 lipid binding
567 GO0009108 34 -0.201 117.2 coenzyme biosynthesis
568 GO0004520 10 -0.206 116.9 endodeoxyribonuclease activity
569 GO0005666 9 -0.210 115.8 DNA-directed RNA polymerase III complex
570 GO0016866 8 -0.212 114.9 intramolecular transferase activity
571 GO0016831 7 -0.230 113.3 carboxy-lyase activity
572 GO0016887 89 -0.231 119.3 ATPase activity
573 GO0004620 6 -0.231 114.7 phospholipase activity
574 GO0016818 137 -0.239 119.8 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
575 GO0016817 137 -0.239 119.8 hydrolase activity, acting on acid anhydrides
576 GO0005665 10 -0.241 115.0 DNA-directed RNA polymerase II, core complex
577 GO0000267 53 -0.242 119.5 cell fraction
578 GO0006810 444 -0.252 120.9 transport
579 GO0006897 27 -0.273 116.3 endocytosis
580 GO0000243 8 -0.275 112.2 commitment complex
581 GO0001510 10 -0.276 114.4 RNA methylation
582 GO0008033 17 -0.300 115.7 tRNA processing
583 GO0007010 155 -0.316 119.7 cytoskeleton organization and biogenesis
584 GO0000003 94 -0.331 118.5 reproduction
585 GO0015144 8 -0.338 110.6 carbohydrate transporter activity
586 GO0003777 6 -0.339 110.0 microtubule motor activity
587 GO0005732 19 -0.341 114.3 small nucleolar ribonucleoprotein complex
588 GO0008150 3254 -0.347 121.0 biological_process
589 GO0005575 3254 -0.347 121.0 cellular_component
590 GO0003673 3254 -0.347 121.0 Gene_Ontology
591 GO0015171 17 -0.348 114.4 amino acid transporter activity
592 GO0005624 36 -0.359 116.2 membrane fraction
593 GO0008094 12 -0.362 111.3 DNA dependent ATPase activity
594 GO0004843 12 -0.362 111.3 ubiquitin-specific protease activity
595 GO0016645 8 -0.369 109.5 oxidoreductase activity, acting on the CH-NH group of donors
596 GO0008213 8 -0.369 109.8 protein amino acid alkylation
597 GO0006479 8 -0.369 109.8 protein amino acid methylation
598 GO0016646 7 -0.378 108.3 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
599 GO0006606 32 -0.379 114.8 protein-nucleus import
600 GO0003779 10 -0.382 111.7 actin binding
601 GO0006457 28 -0.392 115.7 protein folding
602 GO0000742 6 -0.393 108.3 karyogamy during conjugation with cellular fusion
603 GO0016283 22 -0.394 114.0 eukaryotic 48S initiation complex
604 GO0005843 22 -0.394 114.0 cytosolic small ribosomal subunit (sensu Eukarya)
605 GO0005685 8 -0.400 108.0 snRNP U1
606 GO0000750 9 -0.407 109.4 signal transduction during conjugation with cellular fusion
607 GO0006650 26 -0.408 113.8 glycerophospholipid metabolism
608 GO0045003 7 -0.408 107.3 double-strand break repair via synthesis-dependent strand annealing
609 GO0005770 7 -0.408 107.9 late endosome
610 GO0004003 7 -0.408 107.9 ATP dependent DNA helicase activity
611 GO0030474 6 -0.420 107.0 spindle pole body duplication (sensu Fungi)
612 GO0015071 6 -0.420 107.5 protein phosphatase type 2C activity
613 GO0007103 6 -0.420 107.0 spindle pole body duplication (sensu Saccharomyces)
614 GO0006301 6 -0.420 107.0 postreplication repair
615 GO0006383 20 -0.432 113.0 transcription from Pol III promoter
616 GO0030001 21 -0.433 112.3 metal ion transport
617 GO0016573 21 -0.433 112.6 histone acetylation
618 GO0006739 7 -0.438 106.7 NADPH metabolism
619 GO0046915 11 -0.442 108.5 transition metal ion transporter activity
620 GO0004857 11 -0.442 108.5 enzyme inhibitor activity
621 GO0006893 13 -0.443 109.1 Golgi to plasma membrane transport
622 GO0008234 17 -0.444 112.0 cysteine-type peptidase activity
623 GO0006944 22 -0.446 112.3 membrane fusion
624 GO0007126 67 -0.447 116.4 meiosis
625 GO0015149 6 -0.447 106.3 hexose transporter activity
626 GO0015145 6 -0.447 106.3 monosaccharide transporter activity
627 GO0005759 84 -0.451 116.2 mitochondrial matrix
628 GO0016814 11 -0.478 107.9 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
629 GO0000152 11 -0.478 107.4 nuclear ubiquitin ligase complex
630 GO0000041 14 -0.493 109.8 transition metal ion transport
631 GO0005515 150 -0.495 118.0 protein binding
632 GO0006979 22 -0.497 111.4 response to oxidative stress
633 GO0006526 7 -0.497 104.7 arginine biosynthesis
634 GO0003676 272 -0.501 118.7 nucleic acid binding
635 GO0005667 86 -0.524 116.9 transcription factor complex
636 GO0005057 8 -0.526 104.9 receptor signaling protein activity
637 GO0006409 18 -0.526 109.4 tRNA-nucleus export
638 GO0004702 6 -0.528 103.2 receptor signaling protein serine/threonine kinase activity
639 GO0006302 24 -0.546 111.1 double-strand break repair
640 GO0000109 12 -0.553 106.2 nucleotide excision repair complex
641 GO0016407 27 -0.554 111.6 acetyltransferase activity
642 GO0007534 7 -0.557 102.1 gene conversion at MAT locus
643 GO0007533 7 -0.557 102.1 mating-type switching/recombination
644 GO0003684 7 -0.557 102.3 damaged DNA binding
645 GO0016043 721 -0.574 119.6 cell organization and biogenesis
646 GO0030481 6 -0.582 101.7 septin ring (sensu Fungi)
647 GO0000144 6 -0.582 101.7 septin ring (sensu Saccharomyces)
648 GO0005085 11 -0.586 104.5 guanyl-nucleotide exchange factor activity
649 GO0019843 7 -0.587 101.0 rRNA binding
650 GO0000741 8 -0.588 102.5 karyogamy
651 GO0000740 8 -0.588 102.5 nuclear membrane fusion
652 GO0007062 15 -0.590 107.5 sister chromatid cohesion
653 GO0009101 45 -0.598 113.7 glycoprotein biosynthesis
654 GO0006486 45 -0.598 113.7 protein amino acid glycosylation
655 GO0006267 7 -0.616 100.6 pre-replicative complex formation and maintenance
656 GO0005847 10 -0.630 104.0 mRNA cleavage and polyadenylation specificity factor complex
657 GO0000154 10 -0.630 104.5 rRNA modification
658 GO0016570 38 -0.633 112.6 histone modification
659 GO0016569 38 -0.633 112.6 covalent chromatin modification
660 GO0030261 20 -0.634 108.0 chromosome condensation
661 GO0000136 6 -0.662 98.3 mannosyltransferase complex
662 GO0045002 9 -0.669 101.3 double-strand break repair via single-strand annealing
663 GO0015629 64 -0.683 113.2 actin cytoskeleton
664 GO0000070 20 -0.685 107.3 mitotic chromosome segregation
665 GO0045454 6 -0.689 97.3 cell redox homeostasis
666 GO0030503 6 -0.689 97.3 regulation of redox homeostasis
667 GO0005730 122 -0.694 116.0 nucleolus
668 GO0005622 2654 -0.696 119.7 intracellular
669 GO0006487 32 -0.698 109.9 N-linked glycosylation
670 GO0006626 24 -0.700 108.7 protein-mitochondrial targeting
671 GO0005782 10 -0.701 102.7 peroxisomal matrix
672 GO0000054 10 -0.701 102.2 ribosome-nucleus export
673 GO0042144 9 -0.702 100.6 vacuole fusion (non-autophagic)
674 GO0019953 51 -0.704 112.1 sexual reproduction
675 GO0000747 51 -0.704 112.1 conjugation with cellular fusion
676 GO0000746 51 -0.704 112.1 conjugation
677 GO0005840 116 -0.710 115.2 ribosome
678 GO0007119 6 -0.716 96.8 isotropic bud growth
679 GO0006730 6 -0.716 96.8 one-carbon compound metabolism
680 GO0006865 18 -0.717 105.8 amino acid transport
681 GO0006610 18 -0.717 105.3 ribosomal protein-nucleus import
682 GO0006608 18 -0.717 105.3 snRNP protein-nucleus import
683 GO0006607 18 -0.717 105.3 NLS-bearing substrate-nucleus import
684 GO0006408 18 -0.717 105.3 snRNA-nucleus export
685 GO0000301 9 -0.734 99.4 retrograde (vesicle recycling within Golgi) transport
686 GO0016846 7 -0.736 96.7 carbon-sulfur lyase activity
687 GO0006743 7 -0.736 96.3 ubiquinone metabolism
688 GO0030433 10 -0.736 101.8 ER-associated protein catabolism
689 GO0006473 26 -0.737 107.8 protein amino acid acetylation
690 GO0000027 23 -0.741 106.6 ribosomal large subunit assembly and maintenance
691 GO0009063 6 -0.743 95.3 amino acid catabolism
692 GO0005543 8 -0.745 97.1 phospholipid binding
693 GO0007121 22 -0.752 106.0 polar budding
694 GO0000723 13 -0.757 101.4 telomere maintenance
695 GO0006268 7 -0.765 95.9 DNA unwinding
696 GO0004725 7 -0.765 95.4 protein tyrosine phosphatase activity
697 GO0015268 6 -0.770 94.7 alpha-type channel activity
698 GO0015267 6 -0.770 94.7 channel/pore class transporter activity
699 GO0007030 6 -0.770 94.5 Golgi organization and biogenesis
700 GO0030480 17 -0.779 105.7 contractile ring (sensu Fungi)
701 GO0005826 17 -0.779 105.7 contractile ring
702 GO0000142 17 -0.779 105.7 contractile ring (sensu Saccharomyces)
703 GO0016072 12 -0.783 100.7 rRNA metabolism
704 GO0009100 46 -0.797 111.8 glycoprotein metabolism
705 GO0000784 11 -0.800 98.9 nuclear chromosome, telomeric region
706 GO0000781 11 -0.800 98.9 chromosome, telomeric region
707 GO0003767 10 -0.807 99.0 co-chaperone activity
708 GO0005830 48 -0.810 111.1 cytosolic ribosome (sensu Eukarya)
709 GO0004402 12 -0.821 99.8 histone acetyltransferase activity
710 GO0030677 6 -0.824 92.0 ribonuclease P complex
711 GO0006269 6 -0.824 92.2 DNA replication, priming
712 GO0005655 6 -0.824 92.0 nucleolar ribonuclease P complex
713 GO0004526 6 -0.824 92.0 ribonuclease P activity
714 GO0006270 17 -0.827 104.7 DNA replication initiation
715 GO0005842 21 -0.833 104.9 cytosolic large ribosomal subunit (sensu Eukarya)
716 GO0030176 13 -0.835 99.4 integral to endoplasmic reticulum membrane
717 GO0000245 11 -0.836 97.5 spliceosome assembly
718 GO0005885 6 -0.851 91.8 Arp2/3 protein complex
719 GO0000124 14 -0.858 100.6 SAGA complex
720 GO0016891 12 -0.860 98.4 endoribonuclease activity, producing 5'-phosphomonoesters
721 GO0030488 9 -0.866 95.8 tRNA methylation
722 GO0008238 11 -0.872 96.9 exopeptidase activity
723 GO0016810 39 -0.875 109.7 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
724 GO0019774 6 -0.878 90.3 proteasome core complex, beta-subunit complex (sensu Eukarya)
725 GO0005658 6 -0.878 90.5 alpha DNA polymerase:primase complex
726 GO0000087 78 -0.882 112.0 M phase of mitotic cell cycle
727 GO0003887 16 -0.882 101.2 DNA-directed DNA polymerase activity
728 GO0004386 48 -0.890 110.4 helicase activity
729 GO0000123 32 -0.890 106.5 histone acetyltransferase complex
730 GO0000084 68 -0.890 111.4 S phase of mitotic cell cycle
731 GO0005816 34 -0.891 106.4 spindle pole body
732 GO0005815 34 -0.891 106.4 microtubule organizing center
733 GO0012505 128 -0.893 114.9 endomembrane system
734 GO0003724 29 -0.898 106.8 RNA helicase activity
735 GO0006333 12 -0.898 97.8 chromatin assembly/disassembly
736 GO0005488 462 -0.899 117.4 binding
737 GO0016811 23 -0.901 103.9 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
738 GO0016071 49 -0.901 109.2 mRNA metabolism
739 GO0003682 13 -0.913 97.9 chromatin binding
740 GO0000922 37 -0.916 107.7 spindle pole
741 GO0006260 67 -0.921 111.3 DNA replication
742 GO0042221 25 -0.921 104.4 response to chemical substance
743 GO0008186 19 -0.937 102.0 RNA dependent ATPase activity
744 GO0006289 19 -0.937 102.8 nucleotide-excision repair
745 GO0004004 19 -0.937 102.0 ATP dependent RNA helicase activity
746 GO0000749 20 -0.938 102.8 response to pheromone during conjugation with cellular fusion
747 GO0006515 11 -0.944 94.8 misfolded or incompletely synthesized protein catabolism
748 GO0000172 7 -0.944 89.0 ribonuclease MRP complex
749 GO0000171 7 -0.944 89.0 ribonuclease MRP activity
750 GO0042277 10 -0.948 95.9 peptide binding
751 GO0016860 10 -0.948 95.9 intramolecular isomerase activity
752 GO0005048 10 -0.948 95.9 signal sequence binding
753 GO0006418 18 -0.957 100.1 amino acid activation
754 GO0042054 6 -0.959 87.5 histone methyltransferase activity
755 GO0018024 6 -0.959 87.5 histone-lysine N-methyltransferase activity
756 GO0016571 6 -0.959 87.5 histone methylation
757 GO0000727 6 -0.959 87.8 double-strand break repair via break-induced replication
758 GO0046021 7 -0.974 88.3 regulation of transcription from Pol II promoter, mitotic
759 GO0007070 7 -0.974 88.3 negative regulation of transcription from Pol II promoter, mitotic
760 GO0005675 7 -0.974 88.3 transcription factor TFIIH complex
761 GO0015935 42 -0.985 107.4 small ribosomal subunit
762 GO0006365 37 -0.985 106.9 35S primary transcript processing
763 GO0006999 20 -0.988 101.2 nuclear pore organization and biogenesis
764 GO0005663 8 -0.996 89.2 DNA replication factor C complex
765 GO0008283 361 -1.002 116.9 cell proliferation
766 GO0004549 7 -1.003 87.1 tRNA-specific ribonuclease activity
767 GO0008026 27 -1.004 103.7 ATP dependent helicase activity
768 GO0007034 24 -1.007 102.4 vacuolar transport
769 GO0003774 11 -1.015 92.3 motor activity
770 GO0005874 17 -1.019 100.5 microtubule
771 GO0005844 8 -1.027 88.4 polysome
772 GO0000011 9 -1.029 90.0 vacuole inheritance
773 GO0016298 13 -1.031 94.8 lipase activity
774 GO0006752 25 -1.032 102.6 group transfer coenzyme metabolism
775 GO0019239 7 -1.033 86.7 deaminase activity
776 GO0008250 7 -1.033 86.9 oligosaccharyl transferase complex
777 GO0004579 7 -1.033 86.9 dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity
778 GO0004576 7 -1.033 86.9 oligosaccharyl transferase activity
779 GO0005763 20 -1.039 100.2 mitochondrial small ribosomal subunit
780 GO0000314 20 -1.039 100.2 organellar small ribosomal subunit
781 GO0017119 6 -1.040 84.3 Golgi transport complex
782 GO0000725 12 -1.051 93.2 recombinational repair
783 GO0000724 12 -1.051 93.2 double-strand break repair via homologous recombination
784 GO0006272 11 -1.051 91.3 leading strand elongation
785 GO0016462 7 -1.063 85.3 pyrophosphatase activity
786 GO0006888 41 -1.066 107.1 ER to Golgi transport
787 GO0042257 26 -1.066 101.3 ribosomal subunit assembly
788 GO0007067 77 -1.076 110.7 mitosis
789 GO0003678 15 -1.077 96.7 DNA helicase activity
790 GO0016896 21 -1.083 99.0 exoribonuclease activity, producing 5'-phosphomonoesters
791 GO0004532 21 -1.083 99.0 exoribonuclease activity
792 GO0009310 7 -1.093 84.0 amine catabolism
793 GO0000329 30 -1.102 102.8 vacuolar membrane (sensu Fungi)
794 GO0030435 53 -1.113 108.7 sporulation
795 GO0006259 242 -1.114 115.2 DNA metabolism
796 GO0008175 10 -1.125 90.7 tRNA methyltransferase activity
797 GO0000022 9 -1.128 87.3 mitotic spindle elongation
798 GO0006609 20 -1.140 98.0 mRNA-binding (hnRNP) protein-nucleus import
799 GO0042493 16 -1.143 95.9 response to drug
800 GO0008092 29 -1.144 103.0 cytoskeletal protein binding
801 GO0009593 32 -1.145 102.1 perception of chemical substance
802 GO0009582 32 -1.145 102.1 perception of abiotic stimulus
803 GO0009581 32 -1.145 102.1 perception of external stimulus
804 GO0007606 32 -1.145 102.1 chemosensory perception
805 GO0007600 32 -1.145 102.1 sensory perception
806 GO0008298 6 -1.147 80.3 mRNA localization, intracellular
807 GO0005686 7 -1.152 82.9 snRNP U2
808 GO0000092 7 -1.152 82.3 mitotic anaphase B
809 GO0009719 105 -1.153 111.9 response to endogenous stimulus
810 GO0042579 31 -1.157 102.8 microbody
811 GO0005777 31 -1.157 102.8 peroxisome
812 GO0046474 22 -1.160 98.4 glycerophospholipid biosynthesis
813 GO0016886 22 -1.160 98.3 ligase activity, forming phosphoric ester bonds
814 GO0016876 22 -1.160 98.3 ligase activity, forming aminoacyl-tRNA and related compounds
815 GO0016875 22 -1.160 98.3 ligase activity, forming carbon-oxygen bonds
816 GO0008452 22 -1.160 98.3 RNA ligase activity
817 GO0004812 22 -1.160 98.3 tRNA ligase activity
818 GO0019236 30 -1.162 101.3 response to pheromone
819 GO0005485 6 -1.174 79.0 v-SNARE activity
820 GO0016197 16 -1.186 94.1 endosome transport
821 GO0007032 16 -1.186 94.1 endosome organization and biogenesis
822 GO0016410 9 -1.193 85.1 N-acyltransferase activity
823 GO0008080 9 -1.193 85.1 N-acetyltransferase activity
824 GO0006974 102 -1.196 110.3 response to DNA damage stimulus
825 GO0008372 369 -1.201 115.7 cellular_component unknown
826 GO0015940 6 -1.201 78.8 pantothenate biosynthesis
827 GO0015939 6 -1.201 78.8 pantothenate metabolism
828 GO0006644 42 -1.202 104.5 phospholipid metabolism
829 GO0005875 12 -1.204 89.4 microtubule associated complex
830 GO0006402 32 -1.209 101.8 mRNA catabolism
831 GO0000001 9 -1.226 84.2 mitochondrion inheritance
832 GO0000090 26 -1.230 98.4 mitotic anaphase
833 GO0016251 39 -1.232 104.5 general RNA polymerase II transcription factor activity
834 GO0015931 46 -1.259 105.5 nucleobase, nucleoside, nucleotide and nucleic acid transport
835 GO0007152 14 -1.264 90.1 spore wall assembly (sensu Saccharomyces)
836 GO0008237 11 -1.266 85.7 metallopeptidase activity
837 GO0030437 47 -1.268 104.3 sporulation (sensu Fungi)
838 GO0016279 7 -1.271 78.1 protein-lysine N-methyltransferase activity
839 GO0016278 7 -1.271 78.1 lysine N-methyltransferase activity
840 GO0008054 7 -1.271 78.4 cyclin catabolism
841 GO0007151 42 -1.275 103.6 sporulation (sensu Saccharomyces)
842 GO0045324 8 -1.278 80.6 late endosome to vacuole transport
843 GO0004177 8 -1.278 80.1 aminopeptidase activity
844 GO0006273 12 -1.281 87.2 lagging strand elongation
845 GO0004519 30 -1.281 99.4 endonuclease activity
846 GO0005838 18 -1.293 93.6 proteasome regulatory particle (sensu Eukarya)
847 GO0016859 7 -1.301 77.9 cis-trans isomerase activity
848 GO0003755 7 -1.301 77.9 peptidyl-prolyl cis-trans isomerase activity
849 GO0000002 13 -1.305 87.4 mitochondrial genome maintenance
850 GO0030384 17 -1.307 94.2 phosphoinositide metabolism
851 GO0006271 23 -1.328 95.1 DNA strand elongation
852 GO0006401 37 -1.330 101.8 RNA catabolism
853 GO0005654 196 -1.332 112.5 nucleoplasm
854 GO0000300 6 -1.336 73.3 peripheral to membrane of membrane fraction
855 GO0008276 10 -1.337 84.7 protein methyltransferase activity
856 GO0030136 20 -1.342 94.7 clathrin-coated vesicle
857 GO0008173 15 -1.342 90.3 RNA methyltransferase activity
858 GO0016192 145 -1.351 111.7 vesicle-mediated transport
859 GO0007091 9 -1.357 80.3 mitotic metaphase/anaphase transition
860 GO0007049 318 -1.362 114.0 cell cycle
861 GO0006284 6 -1.363 72.3 base-excision repair
862 GO0000279 146 -1.366 111.2 M phase
863 GO0030471 24 -1.366 95.9 spindle pole body and microtubule cycle (sensu Fungi)
864 GO0007102 24 -1.366 95.9 spindle pole body and microtubule cycle (sensu Saccharomyces)
865 GO0006399 38 -1.383 101.6 tRNA metabolism
866 GO0000080 14 -1.386 87.0 G1 phase of mitotic cell cycle
867 GO0042244 15 -1.387 89.2 spore wall assembly
868 GO0030476 15 -1.387 89.2 spore wall assembly (sensu Fungi)
869 GO0003754 54 -1.387 104.9 chaperone activity
870 GO0045132 6 -1.390 71.5 meiotic chromosome segregation
871 GO0015631 9 -1.390 79.3 tubulin binding
872 GO0005635 51 -1.398 103.1 nuclear membrane
873 GO0005657 27 -1.398 96.7 replication fork
874 GO0006625 8 -1.404 76.6 protein-peroxisome targeting
875 GO0008170 16 -1.404 89.8 N-methyltransferase activity
876 GO0006913 62 -1.417 104.9 nucleocytoplasmic transport
877 GO0004521 15 -1.431 88.9 endoribonuclease activity
878 GO0006511 65 -1.433 104.1 ubiquitin-dependent protein catabolism
879 GO0016789 21 -1.433 92.9 carboxylic ester hydrolase activity
880 GO0006407 21 -1.433 92.9 rRNA-nucleus export
881 GO0000114 10 -1.443 81.8 G1-specific transcription in mitotic cell cycle
882 GO0007021 6 -1.444 69.5 tubulin folding
883 GO0007005 64 -1.458 104.6 mitochondrion organization and biogenesis
884 GO0005524 8 -1.466 74.5 ATP binding
885 GO0016741 54 -1.469 103.6 transferase activity, transferring one-carbon groups
886 GO0016944 10 -1.479 80.1 Pol II transcription elongation factor activity
887 GO0005856 126 -1.480 109.3 cytoskeleton
888 GO0016787 396 -1.481 114.6 hydrolase activity
889 GO0000226 55 -1.485 103.1 microtubule cytoskeleton organization and biogenesis
890 GO0008654 33 -1.489 98.8 phospholipid biosynthesis
891 GO0016684 6 -1.498 67.5 oxidoreductase activity, acting on peroxide as acceptor
892 GO0005876 11 -1.517 78.2 spindle microtubule
893 GO0005669 11 -1.517 78.7 transcription factor TFIID complex
894 GO0006400 22 -1.518 91.4 tRNA modification
895 GO0045005 15 -1.519 86.0 maintenance of fidelity during DNA dependent DNA replication
896 GO0006298 15 -1.519 86.0 mismatch repair
897 GO0004527 30 -1.521 95.8 exonuclease activity
898 GO0006611 31 -1.529 96.0 protein-nucleus export
899 GO0006312 19 -1.533 90.8 mitotic recombination
900 GO0006891 16 -1.535 86.9 intra-Golgi transport
901 GO0005794 76 -1.539 105.2 Golgi apparatus
902 GO0006281 84 -1.539 105.0 DNA repair
903 GO0009651 10 -1.550 78.9 salinity response
904 GO0000280 136 -1.552 109.3 nuclear division
905 GO0005680 8 -1.560 71.5 anaphase-promoting complex
906 GO0042255 29 -1.576 95.7 ribosome assembly
907 GO0000175 16 -1.578 85.4 3'-5' exoribonuclease activity
908 GO0006892 34 -1.580 95.8 post-Golgi transport
909 GO0046930 31 -1.591 95.5 pore complex
910 GO0006367 31 -1.591 96.0 transcription initiation from Pol II promoter
911 GO0005643 31 -1.591 95.5 nuclear pore
912 GO0009451 32 -1.592 95.5 RNA modification
913 GO0042727 7 -1.599 67.1 vitamin B2 and derivative biosynthesis
914 GO0042726 7 -1.599 67.1 vitamin B2 and derivative metabolism
915 GO0006384 7 -1.599 67.4 transcription initiation from Pol III promoter
916 GO0003709 7 -1.599 67.4 RNA polymerase III transcription factor activity
917 GO0004175 37 -1.606 97.1 endopeptidase activity
918 GO0000072 37 -1.606 97.6 M-phase specific microtubule process
919 GO0030163 94 -1.616 106.1 protein catabolism
920 GO0016455 12 -1.626 78.7 RNA polymerase II transcription mediator activity
921 GO0008023 12 -1.626 78.3 transcription elongation factor complex
922 GO0005778 12 -1.626 78.7 peroxisomal membrane
923 GO0003711 12 -1.626 78.3 transcriptional elongation regulator activity
924 GO0009231 6 -1.632 62.3 vitamin B2 biosynthesis
925 GO0006771 6 -1.632 62.3 vitamin B2 metabolism
926 GO0005819 47 -1.635 99.5 spindle
927 GO0005684 17 -1.642 87.9 major (U2-dependent) spliceosome
928 GO0006374 8 -1.655 68.6 nuclear mRNA splicing via U2-type spliceosome
929 GO0030554 9 -1.685 70.6 adenyl nucleotide binding
930 GO0006904 8 -1.686 67.4 nonselective vesicle docking
931 GO0030515 17 -1.690 86.5 snoRNA binding
932 GO0005739 404 -1.695 114.0 mitochondrion
933 GO0016788 131 -1.702 108.0 hydrolase activity, acting on ester bonds
934 GO0006360 121 -1.703 107.1 transcription from Pol I promoter
935 GO0015630 57 -1.717 101.9 microtubule cytoskeleton
936 GO0005828 8 -1.717 66.2 kinetochore microtubule
937 GO0007031 24 -1.725 88.9 peroxisome organization and biogenesis
938 GO0019941 66 -1.737 102.9 modification-dependent protein catabolism
939 GO0005486 6 -1.740 58.3 t-SNARE activity
940 GO0016853 29 -1.761 92.4 isomerase activity
941 GO0000754 6 -1.767 57.3 adaptation to pheromone during conjugation with cellular fusion
942 GO0005484 11 -1.768 71.4 SNAP receptor activity
943 GO0015036 8 -1.780 64.9 disulfide oxidoreductase activity
944 GO0006415 8 -1.780 64.1 translational termination
945 GO0006139 768 -1.789 115.4 nucleobase, nucleoside, nucleotide and nucleic acid metabolism
946 GO0005798 6 -1.794 56.3 Golgi vesicle
947 GO0006368 11 -1.804 70.3 RNA elongation from Pol II promoter
948 GO0042764 8 -1.811 63.9 prospore
949 GO0042763 8 -1.811 63.9 immature spore
950 GO0005628 8 -1.811 63.9 prospore membrane
951 GO0000177 9 -1.816 66.9 cytoplasmic exosome (RNase complex)
952 GO0006311 6 -1.821 55.7 meiotic gene conversion
953 GO0006605 138 -1.832 107.1 protein targeting
954 GO0008408 21 -1.834 84.8 3'-5' exonuclease activity
955 GO0008168 52 -1.860 98.3 methyltransferase activity
956 GO0008233 72 -1.865 101.5 peptidase activity
957 GO0007017 59 -1.868 98.6 microtubule-based process
958 GO0000119 14 -1.873 75.4 mediator complex
959 GO0006886 149 -1.875 107.7 intracellular protein transport
960 GO0005801 11 -1.875 68.6 Golgi cis-face
961 GO0006261 54 -1.878 98.0 DNA dependent DNA replication
962 GO0006896 13 -1.893 72.4 Golgi to vacuole transport
963 GO0015031 152 -1.899 107.8 protein transport
964 GO0030490 31 -1.900 90.3 processing of 20S pre-rRNA
965 GO0050658 40 -1.901 94.0 RNA transport
966 GO0050657 40 -1.901 94.0 nucleic acid transport
967 GO0006405 40 -1.901 94.0 RNA-nucleus export
968 GO0007051 27 -1.904 87.7 spindle assembly
969 GO0005839 14 -1.914 74.0 proteasome core complex (sensu Eukarya)
970 GO0004540 38 -1.928 93.8 ribonuclease activity
971 GO0016591 52 -1.941 97.8 DNA-directed RNA polymerase II, holoenzyme
972 GO0030008 8 -1.968 58.4 TRAPP
973 GO0007046 123 -1.975 106.0 ribosome biogenesis
974 GO0009059 240 -2.000 111.0 macromolecule biosynthesis
975 GO0030472 12 -2.009 68.4 mitotic spindle assembly (sensu Fungi)
976 GO0000071 12 -2.009 68.4 mitotic spindle assembly (sensu Saccharomyces)
977 GO0006508 85 -2.024 102.9 proteolysis and peptidolysis
978 GO0005478 17 -2.026 79.1 intracellular transporter activity
979 GO0006996 339 -2.037 111.2 organelle organization and biogenesis
980 GO0007006 9 -2.045 59.3 mitochondrial membrane organization and biogenesis
981 GO0006364 101 -2.048 102.6 rRNA processing
982 GO0016044 16 -2.057 74.2 membrane organization and biogenesis
983 GO0007007 6 -2.063 46.2 inner mitochondrial membrane organization and biogenesis
984 GO0009057 131 -2.085 104.9 macromolecule catabolism
985 GO0003729 61 -2.085 96.7 mRNA binding
986 GO0003723 132 -2.108 105.1 RNA binding
987 GO0007020 23 -2.128 80.9 microtubule nucleation
988 GO0048193 88 -2.133 100.7 Golgi vesicle transport
989 GO0006887 33 -2.144 88.8 exocytosis
990 GO0045045 125 -2.155 104.5 secretory pathway
991 GO0006906 18 -2.156 75.7 nonselective vesicle fusion
992 GO0006352 39 -2.161 91.5 transcription initiation
993 GO0000176 10 -2.186 60.4 nuclear exosome (RNase complex)
994 GO0005200 35 -2.189 88.3 structural constituent of cytoskeleton
995 GO0000502 35 -2.189 88.8 proteasome complex (sensu Eukarya)
996 GO0004518 56 -2.217 95.2 nuclease activity
997 GO0006403 47 -2.221 91.6 RNA localization
998 GO0016194 19 -2.228 76.4 nonselective vesicle exocytosis
999 GO0006406 36 -2.255 89.1 mRNA-nucleus export
1000 GO0007052 25 -2.255 80.1 mitotic spindle assembly
1001 GO0000178 11 -2.269 57.4 exosome (RNase complex)
1002 GO0006461 33 -2.275 86.7 protein complex assembly
1003 GO0006412 236 -2.280 108.9 protein biosynthesis
1004 GO0000228 80 -2.314 97.1 nuclear chromosome
1005 GO0007059 48 -2.323 92.3 chromosome segregation
1006 GO0008757 36 -2.325 88.9 S-adenosylmethionine-dependent methyltransferase activity
1007 GO0042254 138 -2.360 103.6 ribosome biogenesis and assembly
1008 GO0006623 41 -2.384 89.6 protein-vacuolar targeting
1009 GO0005768 31 -2.395 82.9 endosome
1010 GO0046489 15 -2.404 66.9 phosphoinositide biosynthesis
1011 GO0006506 13 -2.442 58.0 GPI anchor biosynthesis
1012 GO0006505 13 -2.442 58.0 GPI anchor metabolism
1013 GO0005634 1109 -2.443 115.0 nucleus
1014 GO0017076 18 -2.443 69.5 purine nucleotide binding
1015 GO0007131 19 -2.476 71.2 meiotic recombination
1016 GO0042158 19 -2.525 70.2 lipoprotein biosynthesis
1017 GO0042157 19 -2.525 70.2 lipoprotein metabolism
1018 GO0006497 19 -2.525 70.2 protein lipidation
1019 GO0003735 83 -2.533 97.5 structural constituent of ribosome
1020 GO0005762 24 -2.546 72.2 mitochondrial large ribosomal subunit
1021 GO0000315 24 -2.546 72.2 organellar large ribosomal subunit
1022 GO0046907 265 -2.554 106.1 intracellular transport
1023 GO0015934 45 -2.561 87.4 large ribosomal subunit
1024 GO0007033 77 -2.577 95.7 vacuole organization and biogenesis
1025 GO0030532 38 -2.609 83.1 small nuclear ribonucleoprotein complex
1026 GO0005761 45 -2.637 86.2 mitochondrial ribosome
1027 GO0000313 45 -2.637 86.2 organellar ribosome
1028 GO0000166 19 -2.674 67.2 nucleotide binding
1029 GO0005198 162 -2.684 102.6 structural molecule activity
1030 GO0000004 842 -2.699 113.5 biological_process unknown
1031 GO0007127 25 -2.700 73.0 meiosis I
1032 GO0005694 90 -2.759 96.0 chromosome
1033 GO0005554 1218 -2.792 113.7 molecular_function unknown
1034 GO0008380 65 -2.798 88.4 RNA splicing
1035 GO0019538 685 -2.799 111.8 protein metabolism
1036 GO0000067 149 -2.818 100.2 DNA replication and chromosome cycle
1037 GO0005681 40 -2.865 79.0 spliceosome complex
1038 GO0007128 23 -2.875 66.1 meiotic prophase I
1039 GO0007028 475 -2.888 109.2 cytoplasm organization and biogenesis
1040 GO0000778 24 -2.905 65.8 condensed nuclear chromosome kinetochore
1041 GO0000777 24 -2.905 65.8 condensed chromosome kinetochore
1042 GO0000776 30 -2.957 71.3 kinetochore
1043 GO0008248 31 -3.014 72.0 pre-mRNA splicing factor activity
1044 GO0030529 205 -3.025 102.0 ribonucleoprotein complex
1045 GO0000780 25 -3.145 64.0 condensed nuclear chromosome, pericentric region
1046 GO0000779 25 -3.145 64.0 condensed chromosome, pericentric region
1047 GO0006310 45 -3.165 79.3 DNA recombination
1048 GO0000775 33 -3.258 71.5 chromosome, pericentric region
1049 GO0000375 58 -3.312 83.0 RNA splicing, via transesterification reactions
1050 GO0000794 38 -3.563 69.3 condensed nuclear chromosome
1051 GO0000793 38 -3.563 69.3 condensed chromosome
1052 GO0006397 79 -3.641 85.6 mRNA processing
1053 GO0000398 55 -3.642 77.3 nuclear mRNA splicing, via spliceosome
1054 GO0000377 55 -3.642 77.3 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
1055 GO0016070 253 -3.776 99.0 RNA metabolism
1056 GO0006396 220 -4.054 97.9 RNA processing